CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8325
Family Name Gonadotropin-releasing hormone receptor ligand 3-[(2R)-2-amino-2-phenylethyl]-5-(2-fluorophenyl)-6-methyl-1-[[2-(trifluoromethyl)phenyl]methyl]pyrimidine-2,4-dione;2,2,2-trifluoroacetic acid family
No. of Seeds 9 No. of Other Members 21
Family Centroid CFAMM00387137 Functional Category Bioactive
Superfamily Disintegrin and Beta-lactamase Binder Superfamily
Class Class 1635

Cousin Family NamesSeedsMembers
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Alpha-1A adrenergic receptor Ligand SNAP-6201 Family 41 94
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Neutrophil elastase inhibitor SureCN7423499 family 5 1
Dipeptidyl peptidase 4 inhibitor SureCN3392451 family 3 2
Dipeptidyl peptidase 4 inhibitor SureCN389715 family 2 2
Gonadotropin-releasing hormone receptor ligand 3-[(2R)-2-amino... 3 1
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 7 8
Glucocorticoid receptor ligand 5-[(3-methylphenyl)methyl]-6-(4... 4 5
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor SureC... 3 8
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 7
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 1
Alpha-1A adrenergic receptor and Histamine H1 receptor ligand ... 13 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 20 2
Substance-P receptor ligand SureCN8936495 family 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 2 0
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 2 1


External ID

Functional Category

Molecule Name

CFAMM00387140 CHEMBL360367 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-5-(2-fluorophenyl)-6-methyl-1-[[2-(trifluoromethyl)phenyl]methyl]pyrimidine-2,4-dione
CFAMM00387146 CHEMBL372680 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-5-[2-(trifluoromethyl)phenyl]pyrimidine-2,4-dione
CFAMM00387139 CHEMBL419270 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-1-[(2,6-difluorophenyl)methyl]-5-(2-fluorophenyl)-6-methylpyrimidine-2,4-dione;2,2,2-trifluoroacetic acid
CFAMM00387132 CHEMBL359810 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-1-[(2,6-difluorophenyl)methyl]-5-(2-fluorophenyl)-6-methylpyrimidine-2,4-dione
CFAMM00387145 CHEMBL365985 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-5-phenylpyrimidine-2,4-dione
CFAMM00387125 CHEMBL193031 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-5-(2-fluorophenyl)-1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]pyrimidine-2,4-dione
CFAMM00387144 CHEMBL362065 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-5-(2-fluorophenyl)-1-[[5-fluoro-2-(trifluoromethyl)phenyl]methyl]-6-methylpyrimidine-2,4-dione
CFAMM00387137 CHEMBL308289 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-5-(2-fluorophenyl)-6-methyl-1-[[2-(trifluoromethyl)phenyl]methyl]pyrimidine-2,4-dione;2,2,2-trifluoroacetic acid
CFAMM00387149 CHEMBL180262 Bioactive 3-[(2R)-2-amino-2-phenylethyl]-1-[(2,6-difluorophenyl)methyl]-5-(2-fluoro-3-methylphenyl)-6-methylpyrimidine-2,4-dione

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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