CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8345
Family Name Corticotropin-releasing factor receptor 1 ligand 3,6-diethyl-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-N-pentan-3-ylpyrazin-2-amine family
No. of Seeds 7 No. of Other Members 8
Family Centroid CFAMM00387275 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 and Corticotropin-releasing factor receptor 1 Binder Superfamily
Class Class 2081

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Corticotropin-releasing factor receptor 1 ligand 6-ethyl-3-met... 6 10
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 8 3
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074EV8... 1 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-077QFZ... 1 7
Corticotropin-releasing factor receptor 1 ligand AGN-PC-04UXCI... 2 0
Macrophage migration inhibitory factor homologue inhibitor 4-[... 2 1
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 1 8
Nuclear receptor ROR-gamma and Cytochrome P450 3A4 ligand NCGC... 1 1
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35


External ID

Functional Category

Molecule Name

CFAMM00387279 CHEMBL1806729 Bioactive 5-(2,4-dimethoxyphenyl)-3,6-diethyl-N-pentan-3-ylpyrazin-2-amine
CFAMM00387269 CHEMBL1807057 Bioactive 3-ethyl-6-methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-N-pentan-3-ylpyrazin-2-amine
CFAMM00387275 CHEMBL1806730 Bioactive 3,6-diethyl-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-N-pentan-3-ylpyrazin-2-amine
CFAMM00387268 CHEMBL1807053 Bioactive 3-methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-6-methyl-N-pentan-3-ylpyrazin-2-amine
CFAMM00387274 CHEMBL1806731 Bioactive 5-(4-ethoxy-2-methoxyphenyl)-3,6-diethyl-N-pentan-3-ylpyrazin-2-amine
CFAMM00387273 CHEMBL1806732 Bioactive 3,6-diethyl-5-(2-methoxy-4-propan-2-yloxyphenyl)-N-pentan-3-ylpyrazin-2-amine
CFAMM00387272 CHEMBL1806736 Bioactive 3,6-diethyl-5-[4-methoxy-2-(trifluoromethoxy)phenyl]-N-pentan-3-ylpyrazin-2-amine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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