CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8346
Family Name Corticotropin-releasing factor receptor 1 ligand 6-ethyl-3-methoxy-5-[2-methoxy-4-(trifluoromethyl)phenyl]-N-pentan-3-ylpyrazin-2-amine family
No. of Seeds 6 No. of Other Members 10
Family Centroid CFAMM00387283 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 and Corticotropin-releasing factor receptor 1 Binder Superfamily
Class Class 2081

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Corticotropin-releasing factor receptor 1 ligand 3,6-diethyl-5... 7 8
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-1-N-(4... 3 9
Melanin-concentrating hormone receptor 1 ligand SureCN5431614 ... 1 2
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Corticotropin-releasing factor receptor 1 ligand 3-ethyl-1-(2-... 5 15
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-077QFZ... 1 7
Corticotropin-releasing factor receptor 1 ligand AGN-PC-077QG0... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
Reverse transcriptase/RNaseH inhibitor AC1L9RKO family 2 17
Acyl-CoA:cholesterol acyltransferase inhibitor 3-(2-chloro-6-m... 4 6
Corticotropin-releasing factor receptor 1 ligand N-[(1R,2S)-2-... 3 0
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 1 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00387283 CHEMBL1807050 Bioactive 6-ethyl-3-methoxy-5-[2-methoxy-4-(trifluoromethyl)phenyl]-N-pentan-3-ylpyrazin-2-amine
CFAMM00387282 CHEMBL1807051 Bioactive 6-ethyl-3-methoxy-5-[4-methoxy-2-(trifluoromethyl)phenyl]-N-pentan-3-ylpyrazin-2-amine
CFAMM00387288 CHEMBL1806734 Bioactive 3,6-diethyl-5-[2-methoxy-4-(trifluoromethyl)phenyl]-N-pentan-3-ylpyrazin-2-amine
CFAMM00387294 CHEMBL1806956 Bioactive 3,6-diethyl-5-[4-methoxy-2-(trifluoromethyl)phenyl]-N-pentan-3-ylpyrazin-2-amine
CFAMM00387285 CHEMBL1807054 Bioactive 3-methoxy-5-[2-methoxy-4-(trifluoromethyl)phenyl]-6-methyl-N-pentan-3-ylpyrazin-2-amine
CFAMM00387291 CHEMBL1807049 Bioactive 6-ethyl-5-(2-ethyl-4-methoxyphenyl)-3-methoxy-N-pentan-3-ylpyrazin-2-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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