CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8350
Family Name Metabotropic glutamate receptor 5 ligand SureCN3866791 family
No. of Seeds 2 No. of Other Members 10
Family Centroid CFAMM00387321 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 5 and Lysine-specific demethylase 4E Binder Superfamily
Class Class 1600

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
26S proteasome Inhibitor Bortezomib Family 7 65
Transient receptor potential cation channel subfamily V member... 16 295
Purine nucleoside phosphorylase Inhibitor BCX-34 Family 2 31
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arof... 3 196
Translocator protein Inhibitor Emapunil Family 7 89
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
XL-888 family 16 85
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Class II cytokine receptor Ligand IL-10 Family 7 45
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A2a and Adenosine receptor A2b Ligand Allox... 1 10
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Transient receptor potential cation channel subfamily V member... 2 26
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5856722 family 3 16
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Cellular tumor antigen p53 inhibitor CHEMBL1551403 family 1 0
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 1
Cannabinoid receptor 2 ligand AGN-PC-0A9SMV family 1 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 13
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(2-amino-6... 13 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Aurora kinase B and Cyclin-dependent kinase 1 inhibitor 7-cycl... 3 16
Adenosine receptor A2b ligand (8Z)-8-(6-oxopyridin-3-ylidene)-... 1 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Metabotropic glutamate receptor 5 ligand 5-methyl-N-(4-methyl-... 1 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Cathepsin K inhibitor SureCN4138062 family 7 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 22
Epidermal growth factor receptor ligand AGN-PC-078X7L family 4 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 0
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 2
Amiloride-sensitive sodium channel subunit alpha ligand AGN-PC... 6 2
Interstitial collagenase inhibitor AGN-PC-03RA86 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00387321 CHEMBL180713 Bioactive SureCN3866791
CFAMM00387320 CHEMBL361973 Bioactive AGN-PC-004MEE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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