CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8359
Family Name Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl-4-[2-methyl-5-[(3-morpholin-4-ylbenzoyl)amino]anilino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide family
No. of Seeds 17 No. of Other Members 3
Family Centroid CFAMM00387382 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 14 and Mitogen-activated protein kinase 11 Binder Superfamily 4
Class Class 195

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Gamma-aminobutyric acid A receptor Ligand Ocinaplon Family 1 10
BIBT986 family 7 96
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
PHA848125 family 13 138
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CC-486 family 7 103
JAK Inhibitor Momelotinib Family 33 83
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family 5 72
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 16
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Insulin receptor and Tyrosine-protein kinase Lck ligand AGN-PC... 1 1
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Orexin receptor type 1 and Orexin receptor type 2 ligand AGN-P... 2 24
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor 1-methyl-8-(... 1 1
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Platelet-activating factor receptor ligand SureCN9384481 family 2 0
Platelet-activating factor receptor ligand 8-bromo-2-[4-(2-met... 2 2
Platelet-activating factor receptor ligand 5-methyl-2-[4-(2-me... 1 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Smoothened homolog inhibitor SureCN1091571 family 2 2
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Mitogen-activated protein kinase 14 inhibitor 3mvm family 6 1
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 5
Adenosine receptor A2a ligand AGN-PC-01LVXW family 2 25
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M4U... 4 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 34 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family 2 3
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 4
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
TGF-beta receptor type-1 ligand 3-[[3-(6-methylpyridin-2-yl)-4... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 11 0
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 2 1
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Heat shock protein HSP 90-beta inhibitor N-[(9R)-4-(3H-imidazo... 1 0
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Coagulation factor X inhibitor SureCN8289965 family 4 5
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
Prothrombin inhibitor 2-[3-cyano-6-(2,2-difluoro-2-pyridin-2-y... 3 0
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Mitogen-activated protein kinase 14 inhibitor methyl 4-[5-(eth... 3 11
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Heat shock protein HSP 90-beta inhibitor 1-(2-amino-4-methylqu... 1 2
Aurora kinase B and Aurora kinase A inhibitor (2S)-1-[4-[[1-[(... 12 4
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
Casein kinase II subunit alpha and Homeodomain-interacting pro... 5 0
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 3 0
Aurora kinase A and Aurora kinase B inhibitor 4-amino-N-[4-(th... 1 1
Cyclin-dependent kinase 2 and Serine/threonine-protein kinase ... 2 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 3 0
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Renin inhibitor AGN-PC-073MLF family 7 6
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
ALK tyrosine kinase receptor ligand N-[6-[[4-(2-hydroxypropan-... 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Tyrosine-protein kinase SYK and Potassium voltage-gated channe... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 12 3
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-[(1-... 9 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 6 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Mitogen-activated protein kinase 14 inhibitor ethyl 4-[5-[(3-f... 2 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 1
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 3 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Mitogen-activated protein kinase 14 inhibitor SureCN294394 family 2 6
Platelet-activating factor receptor ligand 1,8-dimethyl-5-[4-(... 1 0
Type-1 angiotensin II receptor ligand 2-[(2-ethyl-5,7-dimethyl... 5 3
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Glucocorticoid receptor ligand N-[2-[[[5-amino-1-(4-fluorophen... 1 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Egl nine homolog 1 inhibitor 2-[(1,6-diphenylimidazo[4,5-c]pyr... 1 5
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 1 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07B2Q... 6 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07RBL... 5 0
Type-1 angiotensin II receptor ligand 2-[[(5-ethylpyrazolo[1,5... 1 0
Tyrosine-protein kinase Lck and Tyrosine-protein kinase Lyn in... 1 0
Glycogen synthase kinase-3 beta inhibitor 1-(4-amino-1,2,5-oxa... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00387390 CHEMBL261006 Bioactive 4-[5-[(3-fluoro-5-morpholin-4-ylbenzoyl)amino]-2-methylanilino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
CFAMM00387377 CHEMBL254660 Bioactive SureCN12729391
CFAMM00387383 CHEMBL261755 Bioactive 4-[5-[(3-fluoro-5-morpholin-4-ylbenzoyl)amino]-2-methylanilino]-5-methyl-N-propan-2-ylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
CFAMM00387376 CHEMBL260411 Bioactive 4-[5-[(3-fluoro-5-morpholin-4-ylbenzoyl)amino]-2-methylanilino]-N-[(2S)-1-methoxypropan-2-yl]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
CFAMM00387389 CHEMBL259596 Bioactive 4-[5-[(4-cyanobenzoyl)amino]-2-methylanilino]-5-methyl-N-[(1S)-1-phenylethyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
CFAMM00387382 CHEMBL258748 Bioactive N-ethyl-5-methyl-4-[2-methyl-5-[(3-morpholin-4-ylbenzoyl)amino]anilino]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
CFAMM00387375 CHEMBL252168 Bioactive ethyl N-[4-methyl-3-[[5-methyl-6-(propan-2-ylcarbamoyl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]phenyl]carbamate
CFAMM00387381 CHEMBL261845 Bioactive 4-[5-[(3-fluoro-5-morpholin-4-ylbenzoyl)amino]-2-methylanilino]-5-methyl-N-[(1S)-1-phenylethyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
CFAMM00387374 CHEMBL262867 Bioactive N-ethyl-4-[5-[(3-imidazol-1-ylbenzoyl)amino]-2-methylanilino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
CFAMM00387387 CHEMBL442462 Bioactive 4-[5-[(3-fluoro-5-morpholin-4-ylbenzoyl)amino]-2-methylanilino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
CFAMM00387380 CHEMBL251972 Bioactive ethyl N-[3-[[6-(ethylcarbamoyl)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]-4-methylphenyl]carbamate
CFAMM00387393 CHEMBL262592 Bioactive N-ethyl-4-[5-[(3-fluoro-5-morpholin-4-ylbenzoyl)amino]-2-methylanilino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
CFAMM00387386 CHEMBL258794 Bioactive N-[2-(dimethylamino)ethyl]-4-[5-[(3-fluoro-5-morpholin-4-ylbenzoyl)amino]-2-methylanilino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
CFAMM00387379 CHEMBL1807439 Bioactive ethyl N-[3-[(6-benzoyl-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]-4-methylphenyl]carbamate
CFAMM00387392 CHEMBL252373 Bioactive ethyl N-[3-[[6-[[(2S)-butan-2-yl]carbamoyl]-5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]-4-methylphenyl]carbamate
CFAMM00387378 CHEMBL408150 Bioactive 5-methyl-4-[2-methyl-5-[(3-morpholin-4-ylbenzoyl)amino]anilino]-N-[(1S)-1-phenylethyl]pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
CFAMM00387391 CHEMBL261005 Bioactive 4-[5-[(3-fluoro-5-morpholin-4-ylbenzoyl)amino]-2-methylanilino]-N,5-dimethylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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