CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8363
Family Name Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A ligand N-[3-[3-[[2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide family
No. of Seeds 3 No. of Other Members 5
Family Centroid CFAMM00114023 Functional Category Bioactive
Superfamily Tyrosine-protein kinase JAK2 and Aurora kinase A Binder Superfamily
Class Class 712

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 13 100
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BIUF2 family 25 11
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
3-phosphoinositide-dependent protein kinase 1 and Rho-associat... 12 11
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 4
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 2 1
Fibroblast growth factor receptor 1 and Vascular endothelial g... 5 0
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-0CSEAG family 2 1
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 3 8
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 2 0
Serine/threonine-protein kinase Chk1 inhibitor N'-(8-chloro-3-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00387433 CHEMBL1807789 Bioactive N-[3-[3-[[2-methyl-6-(3-morpholin-4-ylpropylamino)pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide
CFAMM00387438 CHEMBL1807785 Bioactive N-[3-[3-[[6-(4-hydroxypiperidin-1-yl)-2-methylpyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27698 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543