CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8385
Family Name Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone family
No. of Seeds 4 No. of Other Members 10
Family Centroid CFAMM00387568 Functional Category Bioactive
Superfamily Metabotropic glutamate receptor 5 Binder Superfamily 8
Class Class 2415

Cousin Family NamesSeedsMembers
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(2... 2 20
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9TG5 family 11 10
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Gamma-aminobutyric acid receptor subunit alpha-2 and Gamma-ami... 6 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 2
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 1 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 13


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00387568 CHEMBL1808868 Bioactive [2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone
CFAMM00387560 CHEMBL1808866 Bioactive [2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-thiophen-2-ylmethanone
CFAMM00387559 CHEMBL1808867 Bioactive [2-[6-(3-chlorophenyl)pyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-2-yl)methanone
CFAMM00387562 CHEMBL1808873 Bioactive [2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-(1,3-thiazol-5-yl)methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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