CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8387
Family Name Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyrazin-2-ylmethanone family
No. of Seeds 1 No. of Other Members 1
Family Centroid CFAMM00387578 Functional Category Bioactive
Superfamily Glycogen phosphorylase, muscle form Inhibitor PSN357 Superfamily
Class Class 913

Cousin Family NamesSeedsMembers
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
26S proteasome Inhibitor Bortezomib Family 7 65
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Cannabinoid receptor 1 Ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 18 41
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
Vasopressin V1b receptor ligand 2-[3-(3-chlorophenyl)-1-oxo-7-... 2 12
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 9 31
Prelamin-A/C and Cellular tumor antigen p53 inhibitor CHEMBL16... 1 7
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 4 10
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 8 1
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
Cannabinoid receptor 1 ligand SureCN4454684 family 2 0
Cannabinoid receptor 1 ligand SureCN4461228 family 1 0
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family 5 2
Cannabinoid receptor 1 ligand AGN-PC-07R6NY family 2 0
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00387578 CHEMBL1808875 Bioactive [2-[6-(3-chlorophenyl)-4-methylpyridin-3-yl]pyrrolidin-1-yl]-pyrazin-2-ylmethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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