CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8396
Family Name Insulin receptor and Insulin-like growth factor 1 receptor ligand 1-[4-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-3-methoxyphenyl]piperazin-1-yl]ethanone family
No. of Seeds 17 No. of Other Members 7
Family Centroid CFAMM00387620 Functional Category Bioactive
Superfamily Vascular endothelial growth factor receptor 2 and Tyrosine-protein kinase Lyn Binder Superfamily
Class Class 3054

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Epidermal growth factor receptor and Receptor tyrosine-protein... 16 89
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
AP26113 family 16 90
ALK Inhibitor ASP3026 Family 2 4
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
B2 bradykinin receptor Ligand FR-173657 Family 44 180
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 6 47
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Vascular endothelial growth factor receptor 2 and Fibroblast g... 3 11
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
Neuropeptide Y receptor type 1 ligand 2-[(4-chlorophenoxy)meth... 5 13
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Vascular endothelial growth factor receptor 2 ligand 1-[4-[6-a... 11 13
Corticotropin-releasing factor receptor 1 ligand N-butyl-9-(2-... 4 5
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 1 3
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Receptor tyrosine-protein kinase erbB-2 ligand 2-[2-[4-[3-chlo... 4 5
ALK tyrosine kinase receptor ligand CHEMBL1946804 family 3 0
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... 8 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Rho-associated protein kinase 1 inhibitor SureCN4716133 family 2 2
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
TRAF2 and NCK-interacting protein kinase and Serine/threonine-... 2 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 4 3
Epidermal growth factor receptor ligand AGN-PC-078X8C family 10 8
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Insulin-like growth factor 1 receptor ligand SureCN310120 family 10 0
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00387606 CHEMBL1809073 Bioactive 1-[4-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-3-methoxyphenyl]piperazin-1-yl]-2-(methylamino)ethanone
CFAMM00387599 CHEMBL1809225 Bioactive 1-[4-[4-[[5-chloro-4-(6-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone
CFAMM00387605 CHEMBL1809070 Bioactive (2S)-1-[4-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-3-methoxyphenyl]piperazin-1-yl]-2-hydroxypropan-1-one
CFAMM00387618 CHEMBL1809198 Bioactive 1-[4-[4-[[5-chloro-4-(8-fluoroimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone
CFAMM00387598 CHEMBL1809224 Bioactive 1-[4-[4-[[5-chloro-4-(6-fluoroimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone
CFAMM00387611 CHEMBL1809069 Bioactive 1-[4-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-3-methoxyphenyl]piperazin-1-yl]-2-hydroxyethanone
CFAMM00387617 CHEMBL1809058 Bioactive 5-chloro-4-imidazo[1,2-a]pyridin-3-yl-N-[2-methoxy-4-(9-oxa-3,7-diazabicyclo[3.3.1]nonan-3-yl)phenyl]pyrimidin-2-amine
CFAMM00387597 CHEMBL1809222 Bioactive 1-[4-[4-[[5-chloro-4-(7-chloroimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone
CFAMM00387610 CHEMBL1809065 Bioactive 5-chloro-4-imidazo[1,2-a]pyridin-3-yl-N-[2-methoxy-4-(4-methylsulfonylpiperazin-1-yl)phenyl]pyrimidin-2-amine
CFAMM00387603 CHEMBL1809074 Bioactive (2S)-2-amino-1-[4-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-3-methoxyphenyl]piperazin-1-yl]propan-1-one
CFAMM00387616 CHEMBL1809059 Bioactive 2-[3-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-3-methoxyphenyl]-9-oxa-3,7-diazabicyclo[3.3.1]nonan-7-yl]ethanol
CFAMM00387609 CHEMBL1809067 Bioactive 4-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-3-methoxyphenyl]piperazine-1-carboxamide
CFAMM00387602 CHEMBL1809075 Bioactive (2R)-2-amino-1-[4-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-3-methoxyphenyl]piperazin-1-yl]propan-1-one
CFAMM00387615 CHEMBL1809205 Bioactive 1-[4-[4-[[5-chloro-4-(7-methylimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone
CFAMM00387614 CHEMBL1809206 Bioactive 1-[4-[4-[[5-chloro-4-(7-methoxyimidazo[1,2-a]pyridin-3-yl)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethanone
CFAMM00387607 CHEMBL1809072 Bioactive 2-amino-1-[4-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-3-methoxyphenyl]piperazin-1-yl]ethanone
CFAMM00387620 CHEMBL1809044 Bioactive 1-[4-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-3-methoxyphenyl]piperazin-1-yl]ethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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