CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8410
Family Name Growth hormone secretagogue receptor type 1 ligand 2-benzylsulfonylcarbonyl-N-[2-[di(propan-2-yl)amino]ethyl]-6-phenylmethoxy-3,4-dihydro-1H-isoquinoline-1-carboxamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00387689 Functional Category Bioactive
Superfamily Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Superfamily
Class Class 590

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Endothelin-1 receptor Ligand Atrasentan Family 127 336
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075O... 14 27
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Matrix metalloproteinase-15 and Matrix metalloproteinase-16 in... 1 0
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 12 54
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 3
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 4 6
Pol polyprotein inhibitor MDL 74538 family 11 1
NS3 inhibitor Proline-Based Macrocycle 24 family 6 6
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Macrophage metalloelastase inhibitor 2-(2,5-dichlorophenyl)sul... 1 1
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 2
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Beta-lactamase and Histone-lysine N-methyltransferase 2A inhib... 1 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00387689 CHEMBL181123 Bioactive 2-benzylsulfonylcarbonyl-N-[2-[di(propan-2-yl)amino]ethyl]-6-phenylmethoxy-3,4-dihydro-1H-isoquinoline-1-carboxamide
CFAMM00387688 CHEMBL182158 Bioactive tert-butyl 1-[2-[di(propan-2-yl)amino]ethylcarbamoyl]-6-(4-methylsulfanylphenoxy)-3,4-dihydro-1H-isoquinoline-2-carboxylate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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