CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8416
Family Name Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)sulfanyl-1-methyl-2-pyridin-2-ylimidazol-4-yl]-2-methylsulfonylpyridine family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00387728 Functional Category Bioactive
Superfamily D(2) dopamine receptor and Interleukin-1 receptor type 1 Binder Superfamily
Class Class 914

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Histamine H1 receptor Ligand Mizolastine Family 14 603
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Corticotropin-releasing factor receptor 1 Ligand CRA1000 Family 4 39
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Mitogen-activated protein kinase 14 Inhibitor 9-benzyl-6-pheny... 5 33
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(4-e... 2 5
Metabotropic glutamate receptor 5 Ligand 4-(4-chlorophenylthio... 4 17
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Protein farnesyltransferase subunit beta Inhibitor BMS-316810 ... 11 18
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Cellular tumor antigen p53 inhibitor F3165-0515 family 2 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 4
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 6 60
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 1 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
5-hydroxytryptamine receptor 6 ligand 3-(5-chlorothiophen-2-yl... 6 1
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M88D fa... 2 1
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Platelet-activating factor receptor ligand 6-(4-fluorophenyl)-... 1 3
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 11 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 15
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 8 19
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 5-[5-chloro-... 2 18
5-hydroxytryptamine receptor 6 ligand 3-(3-chlorophenyl)sulfon... 8 1
5-hydroxytryptamine receptor 6 ligand 3-(3-bromophenyl)sulfony... 3 0
5-hydroxytryptamine receptor 6 ligand AGN-PC-076AT1 family 7 0
Motilin receptor ligand SureCN2004322 family 2 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Tyrosine-protein kinase ITK/TSK and Tyrosine-protein kinase Lc... 2 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 5
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Cannabinoid receptor 2 ligand 4-[[2-tert-butyl-1-(cyclohexylme... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Transient receptor potential cation channel subfamily V member... 9 13
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 2 3
Epidermal growth factor receptor ligand AGN-PC-00RWHW family 3 4
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... 1 0
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0
Dihydrofolate reductase inhibitor 5-[(7-chloro-10-methylsulfan... 1 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Prostaglandin G/H synthase 2 inhibitor AGN-PC-00FW8Y family 1 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00387724 CHEMBL400519 Bioactive 1-[3-[2-(benzenesulfonyl)pyrimidin-4-yl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]-N,N-dimethylmethanamine
CFAMM00387728 CHEMBL1812714 Bioactive 5-[5-(4-chlorophenyl)sulfanyl-1-methyl-2-pyridin-2-ylimidazol-4-yl]-2-methylsulfonylpyridine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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