CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8423
Family Name 72 kDa type IV collagenase and Matrix metalloproteinase-9 inhibitor 5-(4-methylpiperazin-1-yl)-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione family
No. of Seeds 12 No. of Other Members 54
Family Centroid CFAMM00387798 Functional Category Bioactive
Superfamily Matrix metalloproteinase-9 and 72 kDa type IV collagenase Binder Superfamily 7
Class Class 1457

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-benzylsul... 2 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 5 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 1 0
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Motilin receptor and Growth hormone secretagogue receptor type... 1 2
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 1 1
Beta-lactamase and Inositol monophosphatase 1 inhibitor T66475... 1 1
Diphenylmethanes Metabolite 4-Hydroxyphenytoin Family 3 0
4-methyl-3,5-diazabicyclo[2.2.2]octane-2,6-dione NP ZINC620017... 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00387797 CHEMBL1812922 Bioactive 5-[4-(cyclopropylmethyl)-1,4-diazepan-1-yl]-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione
CFAMM00387769 CHEMBL2063430 Bioactive 5-[bis(2-hydroxyethyl)amino]-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione
CFAMM00387762 CHEMBL1812914 Bioactive 5-[4-(cyclopropylmethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione
CFAMM00387801 CHEMBL1812924 Bioactive 5-(4-acetyl-1,4-diazepan-1-yl)-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione
CFAMM00387755 CHEMBL2063518 Bioactive 5-[3-(hydroxymethyl)piperidin-1-yl]-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione
CFAMM00387768 CHEMBL2063433 Bioactive 5-[4-(2-hydroxyethyl)piperidin-1-yl]-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione
CFAMM00387781 CHEMBL192249 Bioactive SureCN5924337
CFAMM00387800 CHEMBL1812925 Bioactive 5-(4-methyl-1,4-diazepan-1-yl)-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione
CFAMM00387813 CHEMBL1946141 Bioactive 5-[4-(2-fluoranylethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione
CFAMM00387767 CHEMBL2063432 Bioactive 5-[4-(2-hydroxyethyl)piperazin-1-yl]-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione
CFAMM00387753 CHEMBL195743 Bioactive SureCN5924499
CFAMM00387798 CHEMBL1812921 Bioactive 5-(4-methylpiperazin-1-yl)-5-(4-phenoxyphenyl)-1,3-diazinane-2,4,6-trione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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