CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8433
Family Name Inhibitor of nuclear factor kappa-B kinase subunit beta inhibitor (6E)-2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-3-yl-1H-pyridine-3-carbonitrile family
No. of Seeds 8 No. of Other Members 3
Family Centroid CFAMM00387907 Functional Category Bioactive
Superfamily Glycogen synthase kinase-3 beta and Myc proto-oncogene protein Inhibitor TWS-119 Superfamily
Class Class 2971

Cousin Family NamesSeedsMembers
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Methionine--tRNA ligase inhibitor 2-[3-[(5-bromo-2-ethoxy-3-me... 9 11
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Corticotropin-releasing factor receptor 1 ligand 3,6-diethyl-5... 7 8
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 2 8
Macrophage migration inhibitory factor homologue inhibitor 4-[... 2 1


External ID

Functional Category

Molecule Name

CFAMM00387906 CHEMBL182749 Bioactive (6E)-2-amino-6-(6-oxo-2-pentoxycyclohexa-2,4-dien-1-ylidene)-4-piperidin-3-yl-1H-pyridine-3-carbonitrile
CFAMM00387905 CHEMBL361233 Bioactive (6E)-2-amino-6-(6-oxo-2-phenylmethoxycyclohexa-2,4-dien-1-ylidene)-4-piperidin-3-yl-1H-pyridine-3-carbonitrile
CFAMM00387904 CHEMBL516203 Bioactive 600734-02-9
CFAMM00387910 CHEMBL181334 Bioactive (6E)-2-amino-6-(6-oxo-2-propoxycyclohexa-2,4-dien-1-ylidene)-4-piperidin-3-yl-1H-pyridine-3-carbonitrile
CFAMM00387903 CHEMBL2375673 Bioactive (6E)-6-(6-amino-5-ethynyl-4-piperidin-4-yl-1H-pyridin-2-ylidene)-5-(cyclopropylmethoxy)cyclohexa-2,4-dien-1-one
CFAMM00387909 CHEMBL181495 Bioactive (6E)-2-amino-6-[2-(2-methylpropoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-3-yl-1H-pyridine-3-carbonitrile
CFAMM00387901 CHEMBL183703 Bioactive (6E)-2-amino-6-[2-(cyclobutylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-3-yl-1H-pyridine-3-carbonitrile
CFAMM00387907 CHEMBL182407 Bioactive (6E)-2-amino-6-[2-(cyclopropylmethoxy)-6-oxocyclohexa-2,4-dien-1-ylidene]-4-piperidin-3-yl-1H-pyridine-3-carbonitrile

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

Last update by



60454 visits since 2014 .........


Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

All rights reserved.

Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links


Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543