CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8436
Family Name Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one family
No. of Seeds 32 No. of Other Members 6
Family Centroid CFAMM00387937 Functional Category Bioactive
Superfamily Beta-lactamase and Androgen receptor Binder Superfamily 3
Class Class 1166

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand phenylpiperazine derivative Arip... 3 53
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Sodium channel protein type 10 subunit alpha and Sodium channe... 1 7
D(2) dopamine receptor Ligand Aplindore Fumarate Family 2 30
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cannabinoid receptor 2 ligand 8-butoxy-N-(2-fluoro-2-phenyleth... 12 7
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Sodium-dependent serotonin transporter and D(2) dopamine recep... 4 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-3... 2 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Trace amine-associated receptor 1 ligand EPPTB family 4 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 5
Transient receptor potential cation channel subfamily V member... 1 0
Renin and Cytochrome P450 3A4 inhibitor SureCN6719989 family 2 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2,... 2 11
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ... 3 3
Motilin receptor ligand SureCN14564469 family 1 6
Galanin receptor type 3 and Alpha-1A adrenergic receptor ligan... 2 16
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 8
Poly [ADP-ribose] polymerase 1 inhibitor 6-[[4-(4-chlorophenyl... 1 0
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Mitogen-activated protein kinase 14 inhibitor (2R)-2-amino-N-[... 9 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Transient receptor potential cation channel subfamily V member... 2 7
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 2 0
Arachidonate 5-lipoxygenase inhibitor ethyl (E)-3-(10H-phenoxa... 1 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075HBO ... 2 44


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00387933 CHEMBL257379 Bioactive (2R)-2-(3-methylphenyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387946 CHEMBL404483 Bioactive (2R)-2-(2-methylsulfanylethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387926 CHEMBL227645 Bioactive SureCN3013641
CFAMM00387952 CHEMBL227590 Bioactive SureCN3021510
CFAMM00387932 CHEMBL395596 Bioactive (3R)-3-methyl-4-(2,2,2-trifluoroethyl)-10-(trifluoromethyl)-3,7-dihydro-2H-pyrido[2,3-h][1,4]benzoxazin-8-one
CFAMM00387945 CHEMBL436644 Bioactive (2S)-2-(hydroxymethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387925 CHEMBL227394 Bioactive SureCN3017862
CFAMM00387938 CHEMBL402039 Bioactive (2R)-2-(methoxymethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387951 CHEMBL256330 Bioactive 1-(2,2,2-trifluoroethyl)-2,9-bis(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387931 CHEMBL227783 Bioactive 1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387944 CHEMBL227305 Bioactive SureCN3018996
CFAMM00387924 CHEMBL389481 Bioactive SureCN3120616
CFAMM00387937 CHEMBL226558 Bioactive (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387930 CHEMBL227784 Bioactive SureCN3023194
CFAMM00387943 CHEMBL255655 Bioactive 2-(propoxymethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387923 CHEMBL247637 Bioactive SureCN5488383
CFAMM00387936 CHEMBL224204 Bioactive SureCN3012010
CFAMM00387949 CHEMBL375907 Bioactive 1-tert-butyl-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387929 CHEMBL227088 Bioactive (2S)-2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387942 CHEMBL401805 Bioactive (2R)-1-(2,2,2-trifluoroethyl)-2,9-bis(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387955 CHEMBL256326 Bioactive 2-(difluoromethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387948 CHEMBL227440 Bioactive 2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387922 CHEMBL224263 Bioactive (2R)-2-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387935 CHEMBL224207 Bioactive SureCN3023071
CFAMM00387928 CHEMBL388997 Bioactive 2-ethyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387954 CHEMBL429311 Bioactive (2R)-2-(fluoromethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387934 CHEMBL257396 Bioactive 2-(ethoxymethyl)-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387927 CHEMBL227408 Bioactive 3-methyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387940 CHEMBL226559 Bioactive (2R)-2-propan-2-yl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one
CFAMM00387953 CHEMBL402835 Bioactive (2R)-2-phenyl-1-(2,2,2-trifluoroethyl)-9-(trifluoromethyl)-3,6-dihydro-2H-pyrido[3,2-g][1,4]benzoxazin-7-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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