CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM844
Family Name Substance-P receptor ligand (1S,2R,5aS,7S,8aR,8bS)-7-amino-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-2,3,5a,6,7,8,8a,8b-octahydro-1H-cyclopenta[a]pyrrolizin-5-one family
No. of Seeds 12 No. of Other Members 2
Family Centroid CFAMM00316475 Functional Category Bioactive
Superfamily Substance-P receptor and Substance-K receptor Binder Superfamily
Class Class 3228

Cousin Family NamesSeedsMembers
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Substance-P receptor ligand (1S,2R,5aS,7R,8aR,8bS)-2-[(1R)-1-[... 11 15
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 6 11
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 6
Substance-P receptor and Potassium voltage-gated channel subfa... 10 0
Substance-P receptor ligand 1-[(1R,2S,3S)-3-[[3,5-bis(trifluor... 7 2
Substance-P receptor ligand 2-[[(1R,2S,3S)-3-[(1R)-1-[3,5-bis(... 5 0
Substance-P receptor ligand 2-[[(1R,2S,3S)-3-[[3,5-bis(trifluo... 6 0
Substance-P receptor ligand (5R)-5-[[[(1R,2S,3S)-3-[(1R)-1-[3,... 6 0
Substance-P receptor ligand (1R,2S,3S)-3-[(1R)-1-[3,5-bis(trif... 8 0
Substance-P receptor ligand (5S)-5-[(3S,4R)-3-[(1R)-1-[3,5-bis... 3 0
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00316472 CHEMBL1097693 Bioactive (6R,7S,8S)-2-amino-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-7-(4-fluorophenyl)-1,2,5,6,7,8-hexahydropyrrolizin-3-one
CFAMM00316465 CHEMBL1258623 Bioactive FIRST ELUDED ISOMER
CFAMM00316471 CHEMBL1256590 Bioactive (1S,2R,5aS,7S,8aR,8bS)-7-(benzylamino)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-2,3,5a,6,7,8,8a,8b-octahydro-1H-cyclopenta[a]pyrrolizin-5-one
CFAMM00316464 CHEMBL1256587 Bioactive (1S,2R,5aR,7R,8aS,8bS)-7-(benzylamino)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-2,3,5a,6,7,8,8a,8b-octahydro-1H-cyclopenta[a]pyrrolizin-5-one
CFAMM00316470 CHEMBL1258967 Bioactive (1S,2R,5aS,7R,8aR,8bS)-7-amino-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-2,3,5a,6,7,8,8a,8b-octahydro-1H-cyclopenta[a]pyrrolizin-5-one
CFAMM00316463 CHEMBL1258852 Bioactive (1S,2R,5aR,7S,8aS,8bS)-7-amino-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-2,3,5a,6,7,8,8a,8b-octahydro-1H-cyclopenta[a]pyrrolizin-5-one
CFAMM00316476 CHEMBL1093751 Bioactive (6R,7S,8R)-1-amino-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-7-(4-fluorophenyl)-1-methyl-5,6,7,8-tetrahydro-2H-pyrrolizin-3-one
CFAMM00316475 CHEMBL1257235 Bioactive (1S,2R,5aS,7S,8aR,8bS)-7-amino-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-2,3,5a,6,7,8,8a,8b-octahydro-1H-cyclopenta[a]pyrrolizin-5-one
CFAMM00316468 CHEMBL1256588 Bioactive (1S,2R,5aR,7S,8aS,8bS)-7-(benzylamino)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-2,3,5a,6,7,8,8a,8b-octahydro-1H-cyclopenta[a]pyrrolizin-5-one
CFAMM00316474 CHEMBL1090742 Bioactive (6R,7S,8R)-1-amino-6-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-7-(4-fluorophenyl)-1,2,5,6,7,8-hexahydropyrrolizin-3-one
CFAMM00316467 CHEMBL1256589 Bioactive (1S,2R,5aS,7R,8aR,8bS)-7-(benzylamino)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-2,3,5a,6,7,8,8a,8b-octahydro-1H-cyclopenta[a]pyrrolizin-5-one
CFAMM00316473 CHEMBL1258732 Bioactive (1S,2R,5aR,7R,8aS,8bS)-7-amino-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(4-fluorophenyl)-2,3,5a,6,7,8,8a,8b-octahydro-1H-cyclopenta[a]pyrrolizin-5-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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