CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM847
Family Name Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate receptor 4 ligand SureCN14263364 family
No. of Seeds 7 No. of Other Members 16
Family Centroid CFAMM00316485 Functional Category Bioactive
Superfamily Beta-lactamase and DNA polymerase beta Binder Superfamily
Class Class 1671

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Histamine H1 receptor Ligand Mepyramine Family 5 65
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
SB1518 family 7 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Histamine H3 receptor Ligand 4-(3-phenoxy-propyl)-1h-imidazole... 26 142
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Histamine H3 receptor Ligand Proxyfan Family 12 32
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Beta-1 adrenergic receptor ligand 1-[4-[2-(5-bromo-1H-imidazol... 3 8
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 14 2
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 1 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 3... 2 10
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Neuropeptide Y receptor type 5 ligand 6-ethylsulfonyl-2-(4-phe... 4 4
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 5
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Glucagon receptor ligand SureCN2647807 family 3 7
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJ2 family 1 0
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Angiopoietin-1 receptor ligand 4-[4-(6-methoxynaphthalen-2-yl)... 6 4
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919280 f... 23 18
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00FHC0 f... 2 0
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2-(dimethyla... 2 1
Putative NP ZINC32497112 Family 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00316493 CHEMBL470511 Bioactive SureCN14263254
CFAMM00316499 CHEMBL1090829 Bioactive SureCN14263239
CFAMM00316485 CHEMBL474418 Bioactive SureCN14263364
CFAMM00316498 CHEMBL515917 Bioactive SureCN14263359
CFAMM00316504 CHEMBL514170 Bioactive SureCN6054437
CFAMM00316483 CHEMBL1093823 Bioactive SureCN6054387
CFAMM00316487 CHEMBL473269 Bioactive [(2R)-2-amino-2-[5-(3-fluoro-4-octoxyphenyl)-1H-imidazol-2-yl]propyl] dihydrogen phosphate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26400 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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