CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8476
Family Name Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)methyl]-N-(4-phenoxypyridin-3-yl)acetamide family
No. of Seeds 8 No. of Other Members 27
Family Centroid CFAMM00388258 Functional Category Bioactive
Superfamily Cationic trypsin and P2Y purinoceptor 1 Binder Superfamily
Class Class 963

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Histamine H3 receptor Ligand GSK239512 Family 2 65
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 31
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Nicotinic acetylcholine receptor Ligand Dianicline Family 6 13
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Hemoglobin subunit alpha Inhibitor 4-[(5-methoxy-2-methylpheno... 3 12
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-((3-methox... 3 9
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Translocator protein inhibitor SureCN13502542 family 20 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(2-methoxy-3-methylpy... 2 3
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 4 1
Translocator protein inhibitor N-methyl-2-(2-oxo-5-pyridin-4-y... 8 15
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 2 7
D(4) dopamine receptor ligand AGN-PC-00SXAZ family 2 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 5 0
P2Y purinoceptor 1 inhibitor 1-(4-tert-butylphenyl)-3-[2-(2-pr... 4 14
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 3 8
Pol polyprotein inhibitor Palinavir deriv. 13 family 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Sodium-dependent serotonin transporter inhibitor SureCN5878703... 4 5
Acyl-CoA:cholesterol acyltransferase inhibitor 3-(2-chloro-6-m... 4 6
Metabotropic glutamate receptor 5 ligand AGN-PC-09QKER family 1 0
Glutamate receptor ionotropic, NMDA 2B and Cytochrome P450 2D6... 2 3
Hormone-sensitive lipase inhibitor AGN-PC-046LTD family 3 8
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Coagulation factor X and Cationic trypsin inhibitor SureCN6578... 4 11
3-(4-methoxyphenyl)-1-pyrrol-1-ylpropan-1-one NP Agn-pc-08zsfd... 1 1
(4-methoxyphenyl)-[(2R)-2-pyridin-3-ylpiperidin-1-yl]phosphina... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00388242 CHEMBL1817978 Bioactive N-(6-fluoro-4-phenoxypyridin-3-yl)-N-[(2-methoxyphenyl)methyl]acetamide
CFAMM00388246 CHEMBL2070806 Bioactive N-[[2-(2-fluoroethoxy)pyridin-3-yl]methyl]-N-(2-phenoxyphenyl)acetamide
CFAMM00388241 CHEMBL2070787 Bioactive N-[[3-(2-fluoroethoxy)phenyl]methyl]-N-(4-phenoxypyridin-3-yl)acetamide
CFAMM00388259 CHEMBL2070797 Bioactive N-[[2-(2-fluoroethoxy)-5-methoxyphenyl]methyl]-N-(2-phenoxypyridin-3-yl)acetamide
CFAMM00388240 CHEMBL2070809 Bioactive 2-fluoro-N-(5-fluoro-2-phenoxyphenyl)-N-[(2-methoxypyridin-3-yl)methyl]acetamide
CFAMM00388258 CHEMBL2070799 Bioactive 2-fluoro-N-[(2-methoxyphenyl)methyl]-N-(4-phenoxypyridin-3-yl)acetamide
CFAMM00388239 CHEMBL2070785 Bioactive N-[(3-methoxyphenyl)methyl]-N-(4-phenoxypyridin-3-yl)acetamide
CFAMM00388243 CHEMBL2070802 Bioactive 2-fluoro-N-[(2-methoxypyridin-3-yl)methyl]-N-(2-phenoxyphenyl)acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27771 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543