CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8478
Family Name Renin inhibitor [(1S,3R,4S)-3-amino-4-hydroxycyclopentyl]-[(3R)-3-[(1S)-1-hydroxy-5-methoxy-1-[2-(2-methylphenoxy)phenyl]pentyl]piperidin-1-yl]methanone family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00388281 Functional Category Bioactive
Superfamily MN-221 Superfamily
Class Class 65

Cousin Family NamesSeedsMembers
Renin Inhibitor Aliskiren Family 28 107
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Renin inhibitor (3R)-3-[(1S)-1-hydroxy-5-methoxy-1-(2-phenoxyp... 1 7
Renin inhibitor [(1S,3R,4S)-3-amino-4-hydroxycyclopentyl]-[(3R... 8 1
Renin inhibitor [(1S,3R,4S)-3-amino-4-hydroxycyclopentyl]-[(3R... 9 0
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0


External ID

Functional Category

Molecule Name

CFAMM00388283 CHEMBL1818049 Bioactive [(1S,3R,4S)-3-amino-4-hydroxycyclopentyl]-[(3R)-3-[(1S)-1-[3-fluoro-2-(2-methylphenoxy)phenyl]-1-hydroxy-5-methoxypentyl]piperidin-1-yl]methanone
CFAMM00388281 CHEMBL1818047 Bioactive [(1S,3R,4S)-3-amino-4-hydroxycyclopentyl]-[(3R)-3-[(1S)-1-hydroxy-5-methoxy-1-[2-(2-methylphenoxy)phenyl]pentyl]piperidin-1-yl]methanone

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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