CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8484
Family Name Dihydrofolate reductase inhibitor 1-[3-(2,4-diaminoquinazolin-7-yl)phenyl]ethanone family
No. of Seeds 2 No. of Other Members 4
Family Centroid CFAMM00190804 Functional Category Bioactive with Natural Product
Superfamily Adenosine receptor A1 and Adenosine receptor A2a Binder Superfamily 7
Class Class 824

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Peptide deformylase, mitochondrial Inhibitor 5-phenylsulfanyl-... 5 23
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Tubulin beta chain Inhibitor 7-methyl-2-m-tolyl-1h-[1,8]naphth... 7 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Histamine H4 receptor Ligand A-943931 Family 14 11
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Corticotropin-releasing factor receptor 1 Ligand N-mesityl-6-m... 3 2
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 11
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 3
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 13 1
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 6 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 0
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Growth hormone secretagogue receptor type 1 ligand SureCN62436... 8 6
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Epidermal growth factor receptor ligand (E)-1-[4-(3-bromoanili... 9 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
Corticotropin-releasing factor receptor 1 ligand [6-[cycloprop... 6 3


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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