CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8487
Family Name Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-6-methylquinazoline-2,4-diamine family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00388342 Functional Category Bioactive
Superfamily Reverse transcriptase Inhibitor Etravirine Superfamily
Class Class 685

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Mitogen-activated protein kinase 12 Inhibitor Birb 796 Family 20 43
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 5 45
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Dihydrofolate reductase inhibitor 3-(2,4-diamino-6-methylquina... 2 1
Dihydrofolate reductase inhibitor 7-(5-chloro-2-ethoxyphenyl)-... 2 1
Histamine H4 receptor and Histamine H3 receptor ligand 7-(fura... 2 2
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Xanthine dehydrogenase/oxidase inhibitor 4-[[4-(2-aminopyrimid... 3 16
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 3 5
Transient receptor potential cation channel subfamily V member... 2 4
Xanthine dehydrogenase/oxidase inhibitor 5-(2-amino-4-oxo-1H-p... 8 30
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Melanin-concentrating hormone receptor 1 ligand SureCN5431614 ... 1 2
Transient receptor potential cation channel subfamily V member... 2 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Adenosine kinase inhibitor SureCN8139139 family 1 1
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
Dual specificity protein kinase CLK4 and Dual specificity tyro... 6 2
Transient receptor potential cation channel subfamily V member... 6 0
Nuclear receptor ROR-gamma and Cytochrome P450 3A4 ligand NCGC... 1 1
Heat shock protein HSP 90-alpha inhibitor 4-[2-Chloro-6-(4,4,4... 2 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00388343 CHEMBL1818127 Bioactive N-[3-[3-(2,4-diaminoquinazolin-7-yl)-4-ethoxyphenyl]phenyl]methanesulfonamide
CFAMM00388342 CHEMBL1818128 Bioactive 7-(2-ethoxynaphthalen-1-yl)-6-methylquinazoline-2,4-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27511 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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