CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8492
Family Name Histamine H3 receptor ligand 2-[4-[4-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]phenyl]phenyl]sulfonyl-1,3-dihydroisoindole family
No. of Seeds 4 No. of Other Members 11
Family Centroid CFAMM00388369 Functional Category Bioactive
Superfamily Histamine H3 receptor and Corticosteroid 11-beta-dehydrogenase isozyme 1 Binder Superfamily
Class Class 2606

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
5-hydroxytryptamine receptor 7 and D(2) dopamine receptor Liga... 3 29
Potassium voltage-gated channel subfamily H member 2 Ligand 4-... 4 26
Alpha-2A adrenergic receptor Ligand SK&F-29661 Family 3 42
Melanin-concentrating hormone receptor 1 Ligand N,n-bis(tosylm... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Oxytocin receptor and Vasopressin V1a receptor Ligand 1'-tosyl... 1 7
Squalene synthase Inhibitor Zwitterionic Sulfobetaine Derivati... 2 20
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 7
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 8 10
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 34
C-C chemokine receptor type 5 ligand methyl N-[1-[(3S)-4-[benz... 3 18
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 6
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 6 4
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 14 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 10
Tryptase alpha/beta-1 inhibitor N-[2-[3-[4-(aminomethyl)phenyl... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-benzyl-4-[(... 3 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 4 0
C-C chemokine receptor type 5 ligand AC1L9YN4 family 2 33
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 2 2
Neuropeptide Y receptor type 5 and Neuropeptide Y receptor typ... 1 5
Histamine H3 receptor and Potassium voltage-gated channel subf... 5 0
Histamine H3 receptor ligand N,N-diethyl-4-[4-[2-[(2R)-2-methy... 4 0
Neuropeptide Y receptor type 5 ligand AGN-PC-0A7RNK family 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00388369 CHEMBL564803 Bioactive 2-[4-[4-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]phenyl]phenyl]sulfonyl-1,3-dihydroisoindole
CFAMM00388380 CHEMBL1818340 Bioactive N-methyl-2-[4-(piperidin-1-ylmethyl)phenyl]-N-propan-2-ylbenzenesulfonamide
CFAMM00388376 CHEMBL1818234 Bioactive (1R,5S)-6-[[4-(2-pyrrolidin-1-ylsulfonylphenyl)phenyl]methyl]-6-azabicyclo[3.2.1]octane

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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