CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8501
Family Name Sodium-dependent serotonin transporter and Sodium-dependent noradrenaline transporter inhibitor (1S)-1-(3,4-dichlorophenyl)-6-[(5-methylpyrazol-1-yl)methyl]-4-azabicyclo[4.1.0]heptane family
No. of Seeds 14 No. of Other Members 6
Family Centroid CFAMM00388423 Functional Category Bioactive
Superfamily Sodium-dependent serotonin transporter and Sodium-dependent noradrenaline transporter Binder Superfamily
Class Class 3476

Cousin Family NamesSeedsMembers
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
D(2) dopamine receptor Ligand Sertindole Family 3 173
Prothrombin Inhibitor 4-[3-(4-chlorophenyl)-1h-pyrazol-5-yl]pi... 7 39
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
Calcium-activated potassium channel subunit alpha-1 Ligand 1-(... 3 3
Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10
Sodium-dependent serotonin transporter and Sodium-dependent no... 5 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00388420 CHEMBL1818456 Bioactive (1S,6R)-1-(3,4-dichlorophenyl)-6-[[5-(trifluoromethyl)pyrazol-1-yl]methyl]-4-azabicyclo[4.1.0]heptane
CFAMM00388413 CHEMBL1818462 Bioactive (1S,6R)-6-[(3-tert-butylpyrazol-1-yl)methyl]-1-(3,4-dichlorophenyl)-4-azabicyclo[4.1.0]heptane
CFAMM00388406 CHEMBL1818547 Bioactive 2-[[(1S)-1-(3,4-dichlorophenyl)-4-azabicyclo[4.1.0]heptan-6-yl]methyl]indazole
CFAMM00388419 CHEMBL1818457 Bioactive (1S,6R)-1-(3,4-dichlorophenyl)-6-[[3-(trifluoromethyl)pyrazol-1-yl]methyl]-4-azabicyclo[4.1.0]heptane
CFAMM00388412 CHEMBL1818461 Bioactive (1S,6R)-1-(3,4-dichlorophenyl)-6-[[3-methyl-5-(trifluoromethyl)pyrazol-1-yl]methyl]-4-azabicyclo[4.1.0]heptane
CFAMM00388425 CHEMBL1818458 Bioactive 2-[[(1S,6R)-1-(3,4-dichlorophenyl)-4-azabicyclo[4.1.0]heptan-6-yl]methyl]pyrazole-3-carbonitrile
CFAMM00388418 CHEMBL1818454 Bioactive (1S,6R)-1-(3,4-dichlorophenyl)-6-[(3,5-dimethylpyrazol-1-yl)methyl]-4-azabicyclo[4.1.0]heptane
CFAMM00388411 CHEMBL1818460 Bioactive (1S,6R)-1-(3,4-dichlorophenyl)-6-[[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]methyl]-4-azabicyclo[4.1.0]heptane
CFAMM00388424 CHEMBL1818459 Bioactive 1-[[(1S,6R)-1-(3,4-dichlorophenyl)-4-azabicyclo[4.1.0]heptan-6-yl]methyl]pyrazole-3-carbonitrile
CFAMM00388417 CHEMBL1818455 Bioactive (1S)-1-(3,4-dichlorophenyl)-6-[(3,5-dimethylpyrazol-1-yl)methyl]-4-azabicyclo[4.1.0]heptane
CFAMM00388423 CHEMBL1818452 Bioactive (1S)-1-(3,4-dichlorophenyl)-6-[(5-methylpyrazol-1-yl)methyl]-4-azabicyclo[4.1.0]heptane
CFAMM00388422 CHEMBL1818453 Bioactive (1S,6R)-1-(3,4-dichlorophenyl)-6-[(4-methylpyrazol-1-yl)methyl]-4-azabicyclo[4.1.0]heptane
CFAMM00388415 CHEMBL1818441 Bioactive 1-[[(1S)-1-(3,4-dichlorophenyl)-4-azabicyclo[4.1.0]heptan-6-yl]methyl]indazole
CFAMM00388421 CHEMBL1818451 Bioactive (1S)-1-(3,4-dichlorophenyl)-6-[(3-methylpyrazol-1-yl)methyl]-4-azabicyclo[4.1.0]heptane

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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