CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8512
Family Name Melanin-concentrating hormone receptor 1 and Melanin-concentrating hormone receptor 1 ligand N-[6-[[acetyl(methyl)amino]methyl]-7,8-dihydronaphthalen-2-yl]-4-(4-chlorophenyl)benzamide family
No. of Seeds 8 No. of Other Members 1
Family Centroid CFAMM00175623 Functional Category Bioactive
Superfamily Apolipoprotein B-100 and Melanin-concentrating hormone receptor 1 Binder Superfamily
Class Class 3113

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Motilin receptor Ligand GSK962040 Family 30 457
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
K-604 family 4 71
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Delta-type opioid receptor Ligand Sb 227122 Family 7 5
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Urokinase-type plasminogen activator Inhibitor 6-(n-phenylcarb... 2 11
Poly [ADP-ribose] polymerase 1 Inhibitor 8-amino-6h,11h-indeno... 3 9
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
MO15-related protein kinase Pfmrk Inhibitor 2-chloro-n-(o-toly... 6 28
D(2) dopamine receptor Ligand PD-168077 Family 6 5
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Vasopressin V2 receptor and Vasopressin V1a receptor ligand N-... 5 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand CH... 3 5
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 1 8
Rho-associated protein kinase 2 inhibitor N-(7-chloro-1-oxo-2H... 13 42
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [2... 2 4
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 15 24
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-5-amino-2-c... 3 4
Vasopressin V2 receptor ligand [2-chloro-4-(prop-2-enylamino)p... 3 14
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 6 5
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 4
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 3
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Prelamin-A/C inhibitor CHEMBL1547148 family 1 8
Cellular tumor antigen p53 and Inositol monophosphatase 1 inhi... 1 12
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 4 19
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Mitogen-activated protein kinase 14 inhibitor 4-chloro-N-cyclo... 2 0
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 0
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 2 2
B1 bradykinin receptor ligand 4-(4-methyl-1-oxophthalazin-2-yl... 5 27
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4796979 f... 5 4
Testosterone 17-beta-dehydrogenase 3 inhibitor AGN-PC-00CHN2 f... 3 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
P2X purinoceptor 7 inhibitor AGN-PC-050YNC family 1 6
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
Mitogen-activated protein kinase 14 inhibitor 3-(2,4-difluoroa... 6 0
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Tankyrase-2 inhibitor 3-chloro-N-(2-methoxyethyl)-4-(4-methyl-... 1 0
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 0
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
Mitogen-activated protein kinase 14 inhibitor 5-(2-chloro-4-fl... 3 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 1
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 1 0
Urotensin-2 receptor and Kappa-type opioid receptor ligand Sur... 2 0
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
P2X purinoceptor 7 inhibitor 2-[4-chloro-3-(trifluoromethyl)ph... 4 1
P2X purinoceptor 7 inhibitor (2S)-2-[5-[[2-(1-adamantyl)acetyl... 1 0
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Cannabinoid receptor 1 ligand SureCN14463736 family 2 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 4 0
C-C chemokine receptor type 5 ligand AC1MHP8Y family 1 0
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 4 6
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 3
Melanin-concentrating hormone receptor 1 ligand 2-[1-(1-cyclop... 1 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand Su... 3 0
Progesterone receptor ligand AGN-PC-00PB7N family 2 1
Acenes Metabolite C.I. Pigment Red 149 Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00388454 CHEMBL1818806 Bioactive 4-(4-chlorophenyl)-N-[6-[[methyl(propanoyl)amino]methyl]-7,8-dihydronaphthalen-2-yl]benzamide
CFAMM00388458 CHEMBL1818803 Bioactive 4-(4-chlorophenyl)-N-[6-(methylaminomethyl)-7,8-dihydronaphthalen-2-yl]benzamide;2,2,2-trifluoroacetic acid
CFAMM00388457 CHEMBL1818801 Bioactive 4-(4-chlorophenyl)-N-[6-(piperidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
CFAMM00388456 CHEMBL1818800 Bioactive 4-(4-chlorophenyl)-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
CFAMM00388455 CHEMBL1818802 Bioactive 4-(4-chlorophenyl)-N-[6-[(4-methylpiperazin-1-yl)methyl]-7,8-dihydronaphthalen-2-yl]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45925 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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