CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8522
Family Name Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)ethylamino]methyl]phenyl]prop-2-enamide family
No. of Seeds 7 No. of Other Members 9
Family Centroid CFAMM00388526 Functional Category Bioactive
Superfamily Prelamin-A/C and Histone deacetylase 1 Binder Superfamily 2
Class Class 1024

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Hepatocyte growth factor receptor Ligand MK-8033 Family 19 42
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Interleukin-1 beta and Interleukin-6 Inhibitor Ibudilast Family 2 11
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Adenosine receptor A1 and Adenosine receptor A2a Ligand FK-838... 4 19
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 5 10
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Transient receptor potential cation channel subfamily V member... 6 23
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Kappa-type opioid receptor and Potassium voltage-gated channel... 10 10
Adenosine receptor A3 Ligand 2-phenyl-2h-pyrazolo[4,3-d]pyrimi... 2 7
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Histone deacetylase Inhibitor ST-5732 Family 8 6
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Corticotropin-releasing factor receptor 1 ligand 3,7-dimethyl-... 3 4
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 18
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 1
Coagulation factor X inhibitor AGN-PC-02WFR7 family 7 13
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 2
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 10 2
Cathepsin D and Beta-secretase 1 inhibitor N-[(2S,3R)-4-[[2-(2... 4 8
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00388523 CHEMBL1819275 Bioactive (E)-N-hydroxy-3-[4-[[2-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)ethyl-propan-2-ylamino]methyl]phenyl]prop-2-enamide
CFAMM00388522 CHEMBL1819274 Bioactive (E)-3-[4-[[2-(2-ethylpyrazolo[1,5-a]pyridin-3-yl)ethyl-propan-2-ylamino]methyl]phenyl]-N-hydroxyprop-2-enamide
CFAMM00388527 CHEMBL1819271 Bioactive (E)-3-[4-[[2-(2-ethylpyrazolo[1,5-a]pyridin-3-yl)ethylamino]methyl]phenyl]-N-hydroxyprop-2-enamide
CFAMM00388520 CHEMBL1819269 Bioactive (E)-N-hydroxy-3-[4-[(2-pyrazolo[1,5-a]pyridin-3-ylethylamino)methyl]phenyl]prop-2-enamide
CFAMM00388526 CHEMBL1819270 Bioactive (E)-N-hydroxy-3-[4-[[2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)ethylamino]methyl]phenyl]prop-2-enamide
CFAMM00388525 CHEMBL1819273 Bioactive (E)-N-hydroxy-3-[4-[[2-(2-methylpyrazolo[1,5-a]pyridin-3-yl)ethyl-propan-2-ylamino]methyl]phenyl]prop-2-enamide
CFAMM00388524 CHEMBL1819272 Bioactive (E)-N-hydroxy-3-[4-[[2-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)ethylamino]methyl]phenyl]prop-2-enamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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