CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8564
Family Name Smoothened homolog and Sonic hedgehog protein inhibitor N-cyclohexyl-4-[3-(1-methylbenzimidazol-2-yl)-1,2,4-oxadiazol-5-yl]piperazine-1-carboxamide family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00388787 Functional Category Bioactive
Superfamily 4-hydroxyphenylpyruvate dioxygenase and Gamma-aminobutyric acid receptor subunit beta-2 Binder Superfamily
Class Class 1355

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
BIBT986 family 7 96
Tryptase Inhibitor Babim Family 12 90
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 5 58
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Ribosomal protein S6 kinase beta-1 and Rho-associated protein ... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 6 0
Vascular endothelial growth factor receptor 2 and Mitogen-acti... 2 2
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 12
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 14
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 2
Smoothened homolog inhibitor N-[(1-morpholin-4-ylcyclopentyl)m... 2 33
Sonic hedgehog protein and Smoothened homolog inhibitor N-(4,4... 2 13
Ribosomal protein S6 kinase alpha-5 inhibitor AGN-PC-075HAD fa... 2 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Glucose-dependent insulinotropic receptor ligand AGN-PC-04YR3D... 11 9
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 12 3
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Ribosomal protein S6 kinase beta-1 and Rho-associated protein ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00388785 CHEMBL1823864 Bioactive N-(4,4-difluorocyclohexyl)-4-[3-(1-methylbenzimidazol-2-yl)-1,2,4-oxadiazol-5-yl]piperazine-1-carboxamide
CFAMM00388784 CHEMBL1822467 Bioactive 4-[3-(1-methylbenzimidazol-2-yl)-1,2,4-oxadiazol-5-yl]-N-[(1-piperidin-1-ylcyclopentyl)methyl]piperazine-1-carboxamide
CFAMM00388787 CHEMBL1823863 Bioactive N-cyclohexyl-4-[3-(1-methylbenzimidazol-2-yl)-1,2,4-oxadiazol-5-yl]piperazine-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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