CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8565
Family Name Sonic hedgehog protein and Smoothened homolog inhibitor N-(4,4-difluorocyclohexyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperazine-1-carboxamide family
No. of Seeds 2 No. of Other Members 13
Family Centroid CFAMM00388771 Functional Category Bioactive
Superfamily Microsomal triglyceride transfer protein large subunit Inhibitor Implitapide Superfamily
Class Class 877

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Histamine H1 receptor Ligand Mizolastine Family 14 603
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Translocator protein Inhibitor Emapunil Family 7 89
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Aromatase Inhibitor NSC-356781 Family 3 10
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 5 58
Prothrombin inhibitor SureCN5854779 family 4 9
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Prelamin-A/C and Putative fructose-1,6-bisphosphate aldolase i... 1 7
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 12
Lysosomal Pro-X carboxypeptidase inhibitor 1-[(2S)-2-(5,6-dich... 3 10
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 1
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Smoothened homolog inhibitor N-[(1-morpholin-4-ylcyclopentyl)m... 2 33
Smoothened homolog and Sonic hedgehog protein inhibitor N-cycl... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 4
Bone morphogenetic protein 1 inhibitor (3R)-6-cyclohexyl-N-hyd... 3 7
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 3-[3-... 4 9
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 3-[3-... 2 0
Bifunctional epoxide hydrolase 2 and Potassium voltage-gated c... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor Su... 4 0
Multidrug resistance-associated protein 1 and Multidrug resist... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00388801 CHEMBL551921 Bioactive N-(2-phenylcyclopropyl)-4-(3-quinolin-2-yl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

38960 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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