CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8566
Family Name Aurora kinase B and Aurora kinase A inhibitor 2-[(3S,4S)-3-hydroxy-4-propan-2-yloxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide family
No. of Seeds 22 No. of Other Members 5
Family Centroid CFAMM00388813 Functional Category Bioactive
Superfamily Aurora kinase A and Aurora kinase B Binder Superfamily 3
Class Class 935

Cousin Family NamesSeedsMembers
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(4-a... 8 11
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Aurora kinase A inhibitor AGN-PC-0A9UUA family 4 1
Aurora kinase B and Aurora kinase A inhibitor 2-[(3S,4S)-3-(2-... 4 0
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-09QXA7 fa... 16 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Insulin-like growth factor 1 receptor and G1/S-specific cyclin... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00388812 CHEMBL1822638 Bioactive 2-[(2S)-4,4-difluoro-2-(hydroxymethyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00388805 CHEMBL1822640 Bioactive 2-[(2S,4S)-4-fluoro-2-(hydroxymethyl)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00388818 CHEMBL2163407 Bioactive 2-[(3R)-3-(2-hydroxyethoxy)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00388803 CHEMBL1822648 Bioactive 2-[(3S,4S)-3-fluoro-4-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00388816 CHEMBL1822651 Bioactive 2-[(3S,4S)-3-hydroxy-4-(2-methoxyethoxy)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00388809 CHEMBL1822637 Bioactive 2-[(2S,4R)-2-(hydroxymethyl)-4-[(2-methylpropan-2-yl)oxy]pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00388802 CHEMBL1822649 Bioactive 2-[(3S,4S)-3-hydroxy-4-(1,1,1-trifluoro-2-methylpropan-2-yl)oxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00388815 CHEMBL1822650 Bioactive 2-[(3S,4S)-3-hydroxy-4-(2-methylbutan-2-yloxy)pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00388808 CHEMBL1822655 Bioactive 2-[(4S)-3-hydroxyimino-4-[(2-methylpropan-2-yl)oxy]pyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00388814 CHEMBL1822653 Bioactive 2-[(3S,4S)-3-(cyclopropylmethoxy)-4-hydroxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide
CFAMM00388807 CHEMBL2163411 Bioactive N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]-2-[(3R)-3-(3-morpholin-4-ylpropoxy)pyrrolidin-1-yl]acetamide
CFAMM00388813 CHEMBL1822652 Bioactive 2-[(3S,4S)-3-hydroxy-4-propan-2-yloxypyrrolidin-1-yl]-N-[4-[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylphenyl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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