CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8573
Family Name Pol polyprotein inhibitor (2R)-2-benzyl-5-[(3S,5R)-3-benzyl-5-[[4-(2-hydroxyethoxy)phenyl]methyl]-2-oxopyrrolidin-1-yl]-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-4-oxopentanamide family
No. of Seeds 11 No. of Other Members 5
Family Centroid CFAMM00388892 Functional Category Bioactive
Superfamily Pol polyprotein and Matrix metalloproteinase-9 Binder Superfamily
Class Class 3076

Cousin Family NamesSeedsMembers
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Plasmepsin-2 Inhibitor KNI-10079 Family 19 8
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-3-hydroxy-6... 40 29
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5R)-3-hydroxy-6... 11 8
Pol polyprotein inhibitor 180968-31-4 family 8 13
Pol polyprotein inhibitor benzyl N-[(2S,3R)-1-[[(2S,3R,4R)-4-(... 5 26
Pol polyprotein inhibitor (2S)-4-benzyl-1-[(2S,4R)-4-benzyl-2-... 10 4
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 4
Pol polyprotein inhibitor (2R,3R,4R,5R)-2,3,4-trihydroxy-N,N'-... 3 3
E3 ubiquitin-protein ligase XIAP inhibitor N-METHYLALANYL-3-ME... 3 14
Pol polyprotein inhibitor MK-944a family 6 1
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Pol polyprotein inhibitor 3-[[(3S,5R)-5-benzyl-1-[(2S,4R)-4-be... 4 0
Pol polyprotein inhibitor (2R,4S)-5-[(5R)-3-[(3-aminophenyl)me... 4 2
Pol polyprotein inhibitor AC1LADII family 12 1
Pol polyprotein inhibitor L-689,502 family 17 2
Pol polyprotein inhibitor SDZ PRI 053 family 8 1
Pol polyprotein inhibitor tert-butyl N-[(2S,3S,5S)-3-hydroxy-5... 4 12
Pol polyprotein inhibitor AC1NS2O6 family 3 0
Pol polyprotein inhibitor (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopy... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00388894 CHEMBL369733 Bioactive (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopyrrolidin-1-yl]-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-2-[[4-(2-hydroxyethoxy)phenyl]methyl]-4-oxopentanamide
CFAMM00388881 CHEMBL183175 Bioactive (2R)-2-benzyl-5-[(3S,5R)-3-benzyl-2-oxo-5-[(4-phenylmethoxyphenyl)methyl]pyrrolidin-1-yl]-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-4-oxopentanamide
CFAMM00388887 CHEMBL361109 Bioactive (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopyrrolidin-1-yl]-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-4-oxo-2-[(4-phenylmethoxyphenyl)methyl]pentanamide
CFAMM00388886 CHEMBL362491 Bioactive 2-[4-[(2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopyrrolidin-1-yl]-2-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl]-4-oxopentyl]phenoxy]ethyl oxane-4-carboxylate
CFAMM00388892 CHEMBL360440 Bioactive (2R)-2-benzyl-5-[(3S,5R)-3-benzyl-5-[[4-(2-hydroxyethoxy)phenyl]methyl]-2-oxopyrrolidin-1-yl]-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-4-oxopentanamide
CFAMM00388885 CHEMBL364878 Bioactive 3-[[(3S,5R)-5-benzyl-1-[(2S,4R)-2-hydroxy-5-[[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-4-[[4-(2-hydroxyethoxy)phenyl]methyl]-5-oxopentyl]-2-oxopyrrolidin-3-yl]methyl]benzamide
CFAMM00388884 CHEMBL182268 Bioactive (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopyrrolidin-1-yl]-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-2-[[4-[2-(2-methoxyethoxy)ethoxy]phenyl]methyl]-4-oxopentanamide
CFAMM00388883 CHEMBL362274 Bioactive (2R)-2-benzyl-5-[(3S,5R)-3-benzyl-5-[[4-(2-morpholin-4-ylethoxy)phenyl]methyl]-2-oxopyrrolidin-1-yl]-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-4-oxopentanamide
CFAMM00388889 CHEMBL185338 Bioactive (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopyrrolidin-1-yl]-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-2-[[4-(2-morpholin-4-ylethoxy)phenyl]methyl]-4-oxopentanamide
CFAMM00388882 CHEMBL363227 Bioactive (2R,4S)-2-benzyl-5-[(3S,5R)-5-benzyl-3-[[3-(cyanomethoxy)phenyl]methyl]-2-oxopyrrolidin-1-yl]-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide
CFAMM00388895 CHEMBL365043 Bioactive (2R,4S)-2-benzyl-5-[5-benzyl-3-[(4-methoxyphenyl)methyl]-2-oxoimidazolidin-1-yl]-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]pentanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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