CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8589
Family Name Sodium-dependent serotonin transporter and 5-hydroxytryptamine receptor 2A ligand N-[3-[4-(3-chloro-2-methylphenyl)piperazin-1-yl]propyl]-5-methyl-1-phenyl-2-propylimidazole-4-carboxamide;hydrochloride family
No. of Seeds 5 No. of Other Members 8
Family Centroid CFAMM00304608 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin transporter Binder Superfamily 2
Class Class 1027

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 16 295
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
IPI-145 family 2 4
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Cannabinoid receptor 1 Ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 18 41
Prothrombin inhibitor SureCN5854779 family 4 9
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-046QKE family 3 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Dipeptidyl peptidase 8 and Dipeptidyl peptidase 4 inhibitor Su... 5 13
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Tyrosine-protein kinase JAK2 inhibitor N-[2-(3-chlorophenyl)-5... 2 11
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Bile acid receptor and Potassium voltage-gated channel subfami... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 1
Prothrombin inhibitor AGN-PC-09QLAK family 10 2
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 14
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 2 0
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 2 1
Cannabinoid receptor 1 ligand SureCN675796 family 5 1
Cannabinoid receptor 1 ligand 1-(4-chlorophenyl)-2-(2,4-dichlo... 2 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 4 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 13
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 3 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 1 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 7 15
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 2 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 5 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Transient receptor potential cation channel subfamily V member... 1 1
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Prostaglandin E synthase inhibitor 2-(2-chloro-6-fluorophenyl)... 9 1
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Dipeptidyl peptidase 4 inhibitor 2-(3-aminopiperidin-1-yl)-3-b... 4 1
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Coagulation factor X inhibitor SureCN1652469 family 2 1
Corticotropin-releasing factor receptor 1 ligand SureCN6323029... 2 13
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Cannabinoid receptor 1 ligand N-(3,3a,4,5,6,6a-hexahydro-1H-cy... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-P... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 9 0
Transient receptor potential cation channel subfamily V member... 1 0
Centromere-associated protein E inhibitor 5-bromo-N-[(3,4-dich... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00389015 CHEMBL567532 Bioactive SureCN1338802

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26854 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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