CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM859
Family Name Serine/threonine-protein kinase mTOR and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform inhibitor SureCN1409698 family
No. of Seeds 8 No. of Other Members 1
Family Centroid CFAMM00310323 Functional Category Bioactive
Superfamily Dihydrofolate reductase and Dual specificity protein kinase TTK Binder Superfamily
Class Class 831

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
SB1518 family 7 103
GDC-0349 family 44 77
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 25 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 0
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 1
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-... 3 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00316623 CHEMBL1092397 Bioactive AGN-PC-07ZD0K
CFAMM00316622 CHEMBL1092037 Bioactive SureCN32248
CFAMM00316621 CHEMBL1092398 Bioactive AGN-PC-07ZD0L
CFAMM00316620 CHEMBL1091359 Bioactive AGN-PC-07ZCI2

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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