CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8591
Family Name Sodium-dependent serotonin transporter and 5-hydroxytryptamine receptor 2A ligand N-[3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propyl]-1-(2-methoxyphenyl)-2,5-dimethylimidazole-4-carboxamide;hydrochloride family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00330627 Functional Category Bioactive
Superfamily DNA ligase Inhibitor 7-(4-methoxyphenyl)pteridine-2,4-diol Superfamily
Class Class 227

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Adenosine receptor A2a Ligand KW-6002 Family 18 195
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 4 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 5 25
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 14 2
5-hydroxytryptamine receptor 3A ligand 2-[(3S)-3-ethylmorpholi... 10 18
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Survival motor neuron protein and Microtubule-associated prote... 2 14
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Cannabinoid receptor 2 ligand [4-(5-tert-butyl-1,3-benzoxazol-... 4 1
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 3 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-[4-(1,3-benzoxazol... 3 4
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17i ... 3 6
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Bifunctional epoxide hydrolase 2 inhibitor 8-(1H-benzimidazole... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 4 3
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Cathepsin S and Cathepsin L1 inhibitor (2S)-2-(1,3-benzoxazol-... 1 9
Gastrin/cholecystokinin type B receptor ligand AGN-PC-077L8M f... 24 10
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
5-hydroxytryptamine receptor 6 ligand SureCN3910449 family 3 15
Tyrosine-protein kinase SYK and Lysine--tRNA ligase inhibitor ... 8 8
Cholecystokinin receptor type A ligand SureCN3132309 family 11 0
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Transient receptor potential cation channel subfamily V member... 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919280 f... 23 18


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00389019 CHEMBL1823095 Bioactive 1-(3,5-dimethoxyphenyl)-N-[3-[4-(2,3-dimethylphenyl)piperazin-1-yl]propyl]-2,5-dimethylimidazole-4-carboxamide;hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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