CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM86
Family Name Substance-P receptor ligand AGN-PC-01ZIXQ family
No. of Seeds 13 No. of Other Members 42
Family Centroid CFAMM00306856 Functional Category Bioactive with Natural Product
Superfamily Histone deacetylase 6 and Histone deacetylase 1 Binder Superfamily
Class Class 1555

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor Ligand Sertindole Family 3 173
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Reverse transcriptase Inhibitor IDX899 Family 2 118
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Setipiprant family 5 118
ABC294640 family 5 75
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Adenosine receptor A3 and Potassium voltage-gated channel subf... 1 18
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
Vasopressin V2 receptor and Vasopressin V1a receptor ligand [2... 2 5
Acetylcholinesterase inhibitor AGN-PC-07ZG1K family 3 0
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 6
Coagulation factor X and Prothrombin inhibitor SureCN763988 fa... 31 86
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Cellular tumor antigen p53 and Ferritin light chain inhibitor ... 1 2
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 20 37
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 5 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Cannabinoid receptor 1 ligand 5-cyano-1-[(3,5-dichlorophenyl)m... 2 0
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Translocator protein inhibitor N-(4-chlorophenyl)-N-methyl-2-(... 2 0
NS5B protein inhibitor AC1NQMYP family 5 0
Melanin-concentrating hormone receptor 2 and Sodium-dependent ... 2 1
Translocator protein inhibitor N,N-diethyl-11-(2-fluoroethyl)-... 14 9
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 2 9
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 1 1
Substance-P receptor ligand SureCN7796965 family 9 1
Substance-P receptor ligand SureCN7790374 family 6 0
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Cathepsin K inhibitor (1R,2R)-2-(6-chloro-1,3,4,5-tetrahydropy... 2 0
Prostaglandin D2 receptor 2 ligand 2-[3-[(3-chlorophenyl)-meth... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Acetylcholinesterase inhibitor N-[6-[4-[(6-chloro-1,2,3,4-tetr... 9 0
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 8
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 4 11
Endothelin B receptor and Endothelin-1 receptor ligand 2-[[(2R... 17 10
Substance-P receptor ligand AGN-PC-004REJ family 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Chymase inhibitor SureCN408571 family 1 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 1
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
Substance-P receptor ligand SureCN7797126 family 1 0
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Translocator protein inhibitor 2-(7-Chloro-5-methyl-4-oxo-3-ph... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN3553433 family 22 0
Glycogen phosphorylase, liver form inhibitor 2-[(1R,2R)-2-[(5-... 3 2
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 2
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 1
Prostaglandin D2 receptor 2 ligand AGN-PC-00QBAU family 1 24
Malate dehydrogenase, mitochondrial inhibitor AGN-PC-0796ZJ fa... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00306877 CHEMBL319046 Bioactive AGN-PC-074U2N
CFAMM00306870 CHEMBL104883 Bioactive AGN-PC-074U0B
CFAMM00306883 CHEMBL102730 Bioactive AGN-PC-074UC5
CFAMM00306876 CHEMBL105420 Bioactive AGN-PC-074UET
CFAMM00306869 CHEMBL105047 Bioactive AGN-PC-01ZIXG
CFAMM00306882 CHEMBL102937 Bioactive AGN-PC-074UBQ
CFAMM00306888 CHEMBL102434 Bioactive SureCN7796972
CFAMM00306860 CHEMBL102811 Bioactive AGN-PC-01ZIWW
CFAMM00306893 CHEMBL103085 Bioactive AGN-PC-074UB9
CFAMM00306886 CHEMBL102382 Bioactive AGN-PC-074UBE
CFAMM00306899 CHEMBL101421 Bioactive AGN-PC-074UB8
CFAMM00306891 CHEMBL105763 Bioactive 3-[5-chloro-2-(4-chlorophenyl)-1-methylindol-3-yl]-1-[4-(cyclohexylmethyl)piperazin-1-yl]propan-1-one
CFAMM00306856 CHEMBL103367 Bioactive AGN-PC-01ZIXQ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26240 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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