CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8608
Family Name Beta-secretase 1 and Beta-secretase 2 inhibitor (5S)-2-amino-5-(1-ethylpyrazol-4-yl)-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methylimidazol-4-one family
No. of Seeds 3 No. of Other Members 39
Family Centroid CFAMM00389146 Functional Category Bioactive
Superfamily Beta-secretase 1 and Cathepsin D Binder Superfamily 3
Class Class 144

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
PHA848125 family 13 138
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Beta-secretase 1 and Beta-secretase 2 inhibitor (5S)-2-amino-5... 2 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Beta-secretase 1 inhibitor (5R)-2-amino-5-cyclopropyl-3-methyl... 1 5
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Beta-secretase 1 inhibitor 3-[5-[(4aR,7aR)-2-amino-3-methyl-4-... 6 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Beta-secretase 1 and Cathepsin D inhibitor (4R)-2'-amino-6-(2-... 2 3
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN4964150 ... 3 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Beta-secretase 1 and Cathepsin D inhibitor 2'-amino-2,2,3'-tri... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00389138 CHEMBL1824344 Bioactive 2-amino-5-(1-butylpyrazol-4-yl)-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methylimidazol-4-one
CFAMM00389146 CHEMBL1824145 Bioactive (5S)-2-amino-5-(1-ethylpyrazol-4-yl)-5-[3-(2-fluoropyridin-3-yl)phenyl]-3-methylimidazol-4-one
CFAMM00389159 CHEMBL1824141 Bioactive 2-amino-5-(1-butylpyrazol-4-yl)-3-methyl-5-(3-pyrimidin-5-ylphenyl)imidazol-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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