CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8613
Family Name Histamine H3 receptor and Sodium-dependent serotonin transporter ligand SureCN2807128 family
No. of Seeds 15 No. of Other Members 1
Family Centroid CFAMM00389181 Functional Category Bioactive
Superfamily Histamine H3 receptor and Sodium-dependent serotonin transporter Binder Superfamily 3
Class Class 280

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Opioid receptor ligand opiate Levorphanol Family 18 537
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 2A Ligand Pimavanserin Family 4 23
D(3) dopamine receptor Ligand U-99194A Family 7 33
CORT-108297 family 46 44
Dapoxetine family 3 40
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Histamine H3 receptor Ligand A-349821 Family 49 228
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 18 25
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Sodium-dependent dopamine transporter and Sodium-dependent nor... 10 9
Tubulin beta chain Inhibitor Colchinol Family 3 109
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 7 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
Estrogen receptor and Estrogen receptor beta ligand SureCN5681... 7 3
D(3) dopamine receptor ligand S 14297 family 1 2
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 117
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 2
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor ligand SureCN5093910 family 3 16
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 4
Carbonic anhydrase 14 and Carbonic anhydrase 9 inhibitor 1-(4-... 2 3
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-(4-methoxyphenox... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 1 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 1 1
Histamine H3 receptor ligand SureCN6071181 family 2 1
7-dehydrocholesterol reductase inhibitor 2-[2-(4-chlorophenyl)... 2 3
Histamine H3 receptor ligand AGN-PC-0765YW family 1 4
Dipeptidyl peptidase 4 inhibitor SureCN8267584 family 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
D(1A) dopamine receptor and D(2) dopamine receptor ligand (2R,... 1 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Transporter and Sodium-dependent serotonin transporter inhibit... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Sigma non-opioid intracellular receptor 1 ligand 4-[[1-[(2-bro... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Estrogen receptor and Estrogen receptor beta ligand SureCN6716... 2 0
Histamine H3 receptor and D(3) dopamine receptor ligand AGN-PC... 1 0
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Histamine H3 receptor and Histamine H1 receptor ligand (NE)-N-... 1 1
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 3
Putative NP ZINC04061066 Family 18 0
Putative NP ZINC04026929 Family 4 0
Putative NP ZINC38201335 Family 8 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00389181 CHEMBL235614 Bioactive SureCN2807128
CFAMM00389180 CHEMBL1824244 Bioactive 2-[4-[4-(3-piperidin-1-ylpropoxy)phenyl]cyclohexyl]-1,3-dihydroisoindole
CFAMM00389186 CHEMBL240466 Bioactive AGN-PC-00R8PY
CFAMM00389178 CHEMBL240883 Bioactive SureCN2807640
CFAMM00389185 CHEMBL240467 Bioactive AGN-PC-00R9GM
CFAMM00389177 CHEMBL393516 Bioactive SureCN2807124
CFAMM00389184 CHEMBL391062 Bioactive AGN-PC-0CWSNL
CFAMM00389176 CHEMBL430373 Bioactive AGN-PC-00R8DY
CFAMM00389175 CHEMBL394209 Bioactive AGN-PC-00R8XS
CFAMM00389182 CHEMBL391284 Bioactive SureCN2810107

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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