CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8621
Family Name Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrrolo[3,2-b]pyridin-3-yl]-piperazin-1-ylmethanone family
No. of Seeds 5 No. of Other Members 12
Family Centroid CFAMM00389272 Functional Category Bioactive with Natural Product
Superfamily Renin and Insulin-like growth factor 1 receptor Binder Superfamily
Class Class 1070

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
Mitogen-activated protein kinase 12 Inhibitor ARRY-797 Family 13 41
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Alpha-1A adrenergic receptor Ligand A-131701 Family 16 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Renin inhibitor SureCN1144364 family 3 15
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Renin inhibitor AGN-PC-09M9MJ family 2 23
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Histamine H3 receptor ligand SureCN2784306 family 5 3
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Renin inhibitor [2-(5-fluoro-2-methylphenoxy)-5-hydroxy-1-phen... 2 0
Renin inhibitor [2-(2,6-dimethylphenoxy)-6-methoxy-1-phenylpyr... 1 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-ph... 5 3
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
G-protein coupled bile acid receptor 1 ligand (4-cyclopropyl-2... 2 1
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-(cy... 3 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
Serine/threonine-protein kinase Chk1 inhibitor 9-(1-methylpyrr... 1 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
P2Y purinoceptor 1 inhibitor N-[2-(2-tert-butylphenoxy)pyridin... 1 0
Tyrosine-protein kinase JAK3 and Activated CDC42 kinase 1 inhi... 4 1
5-hydroxytryptamine receptor 2C ligand SureCN4230099 family 1 1
Pol polyprotein inhibitor Phenprocoumon IndolEtCONH deriv. family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00389274 CHEMBL1825181 Bioactive [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrrolo[2,3-c]pyridin-3-yl]-piperazin-1-ylmethanone
CFAMM00389266 CHEMBL1824944 Bioactive [1-cyclohexyl-2-(2,6-dimethylphenoxy)pyrrolo[3,2-b]pyridin-3-yl]-piperazin-1-ylmethanone
CFAMM00389272 CHEMBL1824936 Bioactive [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrrolo[3,2-b]pyridin-3-yl]-piperazin-1-ylmethanone
CFAMM00389262 CHEMBL1824961 Bioactive [2-(2,6-dimethylphenoxy)-6-hydroxy-1-phenylpyrrolo[3,2-b]pyridin-3-yl]-piperazin-1-ylmethanone
CFAMM00389275 CHEMBL1825187 Bioactive [7-benzyl-2-(5-fluoro-2-methylphenoxy)-1-phenylpyrrolo[2,3-c]pyridin-3-yl]-piperazin-1-ylmethanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26230 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543