CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8647
Family Name Corticotropin-releasing factor receptor 1 ligand 5-N-(2-chloro-4-methoxyphenyl)-6-methyl-7-N,7-N-dipropylpyrazolo[1,5-a]pyrimidine-5,7-diamine family
No. of Seeds 7 No. of Other Members 1
Family Centroid CFAMM00318350 Functional Category Bioactive
Superfamily Cellular tumor antigen p53 and Prelamin-A/C Binder Superfamily
Class Class 1293

Cousin Family NamesSeedsMembers
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Corticotropin-releasing factor receptor 1 Ligand GSK561679 Family 5 6
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Adenosine receptor A3 ligand AGN-PC-07N4XZ family 4 11
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Epidermal growth factor receptor and Tyrosine-protein kinase A... 4 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CC4... 20 7
Epidermal growth factor receptor and Cyclin-dependent kinase 1... 3 4
Proto-oncogene tyrosine-protein kinase Src and Phosphatidylino... 4 20
Tyrosine-protein kinase ABL1 and Tyrosine-protein kinase HCK i... 2 2
Vascular endothelial growth factor receptor 2 ligand F3284-701... 1 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 5
Vascular endothelial growth factor receptor 2 ligand 1-[4-[6-a... 11 13
Vascular endothelial growth factor receptor 2 ligand 1-[4-[6-a... 2 0
Corticotropin-releasing factor receptor 1 ligand N-butyl-9-(2-... 4 5
Neuropeptide Y receptor type 1 ligand CP-671906 family 10 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Corticotropin-releasing factor receptor 1 ligand CHEMBL1819076... 2 0
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 5 1
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Tyrosine-protein kinase JAK2 inhibitor N-[3-chloro-4-(4-methyl... 2 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Glucose-dependent insulinotropic receptor ligand 2-[1-(5-ethyl... 2 1
Mast/stem cell growth factor receptor Kit and Epithelial disco... 3 0
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Motilin receptor ligand SureCN2012437 family 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 14 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Activated CDC42 kinase 1 and Tyrosine-protein kinase Lck inhib... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CCI... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Glucokinase inhibitor AGN-PC-03ZE5E family 1 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00389492 CHEMBL1828900 Bioactive 5-N-(2-chloro-4-methoxyphenyl)-5-N-prop-2-enyl-7-N,7-N-dipropylpyrazolo[1,5-a]pyrimidine-5,7-diamine
CFAMM00389491 CHEMBL1830514 Bioactive 5-N-(2-chloro-4-methoxyphenyl)-5-N-(methoxymethyl)-7-N,7-N-dipropylpyrazolo[1,5-a]pyrimidine-5,7-diamine
CFAMM00389490 CHEMBL1830517 Bioactive 5-N-(2-chloro-4-methoxyphenyl)-6-methyl-7-N,7-N-dipropyl-[1,2,4]triazolo[1,5-a]pyrimidine-5,7-diamine
CFAMM00389488 CHEMBL1828890 Bioactive 5-N-(2-chloro-4-methoxyphenyl)-6-ethyl-7-N,7-N-dipropylpyrazolo[1,5-a]pyrimidine-5,7-diamine
CFAMM00389494 CHEMBL1830523 Bioactive CHEMBL1830523
CFAMM00389493 CHEMBL1828887 Bioactive 5-N-(2-chloro-4-methoxyphenyl)-6-methyl-7-N-pentan-3-ylpyrazolo[1,5-a]pyrimidine-5,7-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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