CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8649
Family Name Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2R)-2-methyloxolane-2-carbonyl]amino]propanoic acid family
No. of Seeds 16 No. of Other Members 23
Family Centroid CFAMM00389516 Functional Category Bioactive with Natural Product
Superfamily Integrin alpha-4 Inhibitor Firategrast Superfamily
Class Class 65

Cousin Family NamesSeedsMembers
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Neprilysin inhibitor SureCN389939 family 5 6
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[4-(ben... 12 20
Integrin beta-1 and Integrin alpha-4 inhibitor AGN-PC-074GDW f... 9 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(3-benz... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[1-(ben... 6 5
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 191
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-2... 2 21
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 2 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 1 0
Caspase-1 inhibitor 3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethox... 1 3
Amine oxidase [flavin-containing] B inhibitor (2S)-1-[[7-[(3-f... 2 15
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00389515 CHEMBL285022 Bioactive (2S)-3-[4-(2,6-dicyclopropyloxyphenyl)phenyl]-2-[[(2R)-2-methyloxolane-2-carbonyl]amino]propanoic acid
CFAMM00389508 CHEMBL290081 Bioactive (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2R)-2,5-dimethyl-3-oxooxolane-2-carbonyl]amino]propanoic acid
CFAMM00389534 CHEMBL36938 Bioactive (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2S)-2-(2-hydroxyethyl)oxolane-2-carbonyl]amino]propanoic acid
CFAMM00389507 CHEMBL290771 Bioactive (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2S)-2-(2-methylpropyl)oxolane-2-carbonyl]amino]propanoic acid
CFAMM00389520 CHEMBL36541 Bioactive (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2S)-2-(2-methoxyethyl)oxolane-2-carbonyl]amino]propanoic acid
CFAMM00389513 CHEMBL37458 Bioactive (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2R)-2-(4-methoxybutyl)oxolane-2-carbonyl]amino]propanoic acid
CFAMM00389506 CHEMBL286660 Bioactive (2S)-2-[[(2R)-3-amino-2,5-dimethyloxolane-2-carbonyl]amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acid
CFAMM00389519 CHEMBL1829035 Bioactive (2R)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2S)-2-(4-methoxybutyl)oxolane-2-carbonyl]amino]propanoic acid
CFAMM00389532 CHEMBL290793 Bioactive (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2R)-2-[3-(dimethylamino)propyl]oxolane-2-carbonyl]amino]propanoic acid
CFAMM00389512 CHEMBL35545 Bioactive (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2S)-2-(2-methylpropanoyl)oxolane-2-carbonyl]amino]propanoic acid
CFAMM00389518 CHEMBL288899 Bioactive (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2R)-2-(3-hydroxypropyl)oxolane-2-carbonyl]amino]propanoic acid
CFAMM00389531 CHEMBL34593 Bioactive (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2S)-2-(3-methoxypropyl)oxolane-2-carbonyl]amino]propanoic acid
CFAMM00389517 CHEMBL435366 Bioactive (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2R)-3-[(4-methoxyphenyl)methylamino]-2,5-dimethyloxolane-2-carbonyl]amino]propanoic acid
CFAMM00389523 CHEMBL418414 Bioactive (2S)-2-[[(2R)-2-butyloxolane-2-carbonyl]amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acid
CFAMM00389516 CHEMBL34498 Bioactive (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2R)-2-methyloxolane-2-carbonyl]amino]propanoic acid
CFAMM00389535 CHEMBL289991 Bioactive (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2S)-2-propan-2-yloxolane-2-carbonyl]amino]propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

38795 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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