CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8665
Family Name Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-[(4-methoxyphenyl)methyl]-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine] family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00389640 Functional Category Bioactive
Superfamily Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,3-c]quinoline Superfamily
Class Class 2208

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Calcitonin gene-related peptide 1 Inhibitor Cizolirtine Family 3 15
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
PF-02545920 family 16 140
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Sigma non-opioid intracellular receptor 1 ligand 1'-butyl-6-me... 23 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-04YWC4... 2 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Smoothened homolog inhibitor AGN-PC-088VBV family 1 2
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Sigma non-opioid intracellular receptor 1 ligand 1-benzyl-1'-p... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Prostaglandin D2 receptor 2 ligand 2-[4-(difluoromethoxy)-2-et... 1 0
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0


External ID

Functional Category

Molecule Name

CFAMM00389640 CHEMBL1829569 Bioactive 6-methoxy-1'-[(4-methoxyphenyl)methyl]-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]
CFAMM00389639 CHEMBL1829570 Bioactive 1'-(furan-2-ylmethyl)-6-methoxy-1-phenylspiro[6,7-dihydropyrano[4,3-c]pyrazole-4,4'-piperidine]

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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