CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8667
Family Name C-C chemokine receptor type 2 and Potassium voltage-gated channel subfamily H member 2 ligand N-[2-[[1-[4-(1,3-benzodioxol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00389646 Functional Category Bioactive
Superfamily C-C chemokine receptor type 2 and Potassium voltage-gated channel subfamily H member 2 Binder Superfamily
Class Class 1704

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Myeloperoxidase Inhibitor AZD5904 Family 1 2
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Elagolix family 43 98
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Guanylate cyclase soluble subunit beta-1 Inhibitor Cinaciguat ... 7 50
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Neutrophil elastase inhibitor SureCN7276506 family 2 7
Histamine H3 receptor ligand 1-(3,4-dimethoxyphenyl)-4-(4-pent... 2 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 1 1
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Neutrophil elastase inhibitor benzyl 2-[2,4,8-trioxo-7-[2-oxo-... 2 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 1 4
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Histamine H3 receptor and Cytochrome P450 2D6 ligand ethyl 4-[... 5 5
Histamine H3 receptor ligand 2-(3,3-difluoropyrrolidin-1-yl)-1... 2 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
B1 bradykinin receptor ligand methyl 2-fluoro-6-[3-fluoro-4-[(... 18 17
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Prothrombin inhibitor CHEMBL2448373 family 3 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 2 6
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
Neutrophil elastase inhibitor SureCN7273831 family 2 2
Histamine H3 receptor ligand SureCN7244264 family 1 0
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 2 20
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Dipeptidyl peptidase 4 inhibitor SureCN5777647 family 1 0
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Calpain-1 catalytic subunit inhibitor (3S)-3-[[4-[2-(methoxyme... 2 4
Prostaglandin D2 receptor ligand (E)-7-[(1S,3S,4R,5R)-4-(1,3-b... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00389643 CHEMBL1829612 Bioactive N-[2-[[1-[4-(4-methoxyphenyl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00389646 CHEMBL1829605 Bioactive N-[2-[[1-[4-(1,3-benzodioxol-5-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27295 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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