CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8668
Family Name C-C chemokine receptor type 2 and Potassium voltage-gated channel subfamily H member 2 ligand N-[2-[[(3R)-1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide;methanesulfonic acid family
No. of Seeds 4 No. of Other Members 11
Family Centroid CFAMM00389653 Functional Category Bioactive
Superfamily C-C chemokine receptor type 2 and Cytochrome P450 2C9 Binder Superfamily
Class Class 2367

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
Substance-P receptor Ligand TAK-637 Family 18 63
Smoothened homolog Inhibitor LDE225 Family 3 76
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
PF-4136309 family 16 27
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Transient receptor potential cation channel subfamily V member... 6 23
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Renin Inhibitor CP-305202 Family 9 30
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
C-C chemokine receptor type 5 ligand (2,4-dimethyl-1-oxidopyri... 5 4
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 6 31
cAMP-dependent protein kinase type II-alpha regulatory subunit... 2 4
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 4 7
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 14
Potassium voltage-gated channel subfamily H member 2 and C-C c... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
C-C chemokine receptor type 2 ligand N-[2-[[(3R)-1-(4-hydroxy-... 4 0
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 3 1
D(4) dopamine receptor ligand AGN-PC-00SXAZ family 2 4
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Sodium channel protein type 9 subunit alpha and Sodium channel... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00389655 CHEMBL1963131 Bioactive N-[2-[[(3R)-1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00389654 CHEMBL1951779 Bioactive N-[2-[[(3R)-1-[4-(6-ethoxypyridin-3-yl)-4-hydroxycyclohexyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00389647 CHEMBL1829619 Bioactive N-[2-[[1-[4-(6-methoxypyridin-3-yl)cyclohexyl]azetidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00389653 CHEMBL1951778 Bioactive N-[2-[[(3R)-1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide;methanesulfonic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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