CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8673
Family Name Corticosteroid 11-beta-dehydrogenase isozyme 1 and Cytochrome P450 3A4 inhibitor (6R)-6-(2-aminoethyl)-3-[(1S)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one family
No. of Seeds 12 No. of Other Members 2
Family Centroid CFAMM00389716 Functional Category Bioactive
Superfamily Cytochrome P450 3A4 and Corticosteroid 11-beta-dehydrogenase isozyme 1 Binder Superfamily
Class Class 2544

Cousin Family NamesSeedsMembers
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[3-... 7 18
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Cytochrome ... 11 4
C-C chemokine receptor type 5 ligand benzyl N-[1-[(4S)-4-(cycl... 1 0
Neuropeptide S receptor ligand N-benzyl-3-oxo-1,1-diphenyl-5,6... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00389713 CHEMBL1829775 Bioactive N-[2-[(6S)-3-[(1S)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]ethyl]methanesulfonamide
CFAMM00389712 CHEMBL1829779 Bioactive (6R)-6-(3-aminopropyl)-3-[(1S)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one
CFAMM00389718 CHEMBL1829772 Bioactive 2-[(6R)-3-[(1S)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]ethylurea
CFAMM00389717 CHEMBL1829771 Bioactive N-[2-[(6R)-3-[(1S)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]ethyl]acetamide
CFAMM00389710 CHEMBL1829782 Bioactive N-[3-[(6R)-3-[(1S)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]propyl]methanesulfonamide
CFAMM00389716 CHEMBL1829770 Bioactive (6R)-6-(2-aminoethyl)-3-[(1S)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-1,3-oxazinan-2-one
CFAMM00389709 CHEMBL1829780 Bioactive 3-[(6R)-3-[(1S)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]propylurea
CFAMM00389715 CHEMBL1829777 Bioactive 3-[(6R)-3-[(1S)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]propanamide
CFAMM00389708 CHEMBL1829769 Bioactive 2-[(6S)-3-[(1S)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-6-yl]acetamide
CFAMM00389714 CHEMBL1829776 Bioactive (6S)-3-[(1S)-1-[4-(2,4-difluorophenyl)phenyl]ethyl]-6-(4-fluorophenyl)-2-oxo-6-[2-(sulfamoylamino)ethyl]-1,3-oxazinane

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27425 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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