CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM87
Family Name Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-2-but-3-enyl-7-(4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid family
No. of Seeds 15 No. of Other Members 28
Family Centroid CFAMM00306928 Functional Category Bioactive with Natural Product
Superfamily Endothelin-1 receptor and Endothelin B receptor Binder Superfamily
Class Class 3074

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Tetomilast family 3 51
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 4 5
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Endothelin-1 receptor and Endothelin B receptor ligand (5S,6R,... 23 8
Endothelin-1 receptor and Endothelin B receptor ligand 3-(1,3-... 1 1
Endothelin-1 receptor and Endothelin B receptor ligand SureCN1... 3 16
Leukotriene B4 receptor 1 ligand AGN-PC-04XM3V family 3 10
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
Insulin-like growth factor-binding protein 4 and Insulin-like ... 4 44
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 7 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 22 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 9 2
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Insulin-like growth factor-binding protein 3 inhibitor (1E)-1-... 2 0
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00306935 CHEMBL430695 Bioactive (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-2-cyclopropyl-7-(4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid
CFAMM00306949 CHEMBL321520 Bioactive (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-7-(4-methoxyphenyl)-2-propoxy-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid
CFAMM00306928 CHEMBL101424 Bioactive (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-2-but-3-enyl-7-(4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid
CFAMM00306921 CHEMBL103001 Bioactive (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-7-(4-methoxyphenyl)-2-methyl-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid
CFAMM00306934 CHEMBL320631 Bioactive (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-2-(ethylaminomethyl)-7-(4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid
CFAMM00306914 CHEMBL102825 Bioactive (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-7-(4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid
CFAMM00306940 CHEMBL305576 Bioactive (5s,6r,7r)-5-(1,3-benzodioxol-5-yl)-2-butyl-7-{2-[(2s)-2-carboxypropyl]-4-methoxyphenyl}-6,7-dihydro-5h-cyclopenta[b]pyridine-6-carboxylic acid
CFAMM00306920 CHEMBL323561 Bioactive (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-2-(3-hydroxypropyl)-7-(4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid
CFAMM00306912 CHEMBL430506 Bioactive (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-2-(ethoxymethyl)-7-(4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid
CFAMM00306925 CHEMBL320208 Bioactive (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-7-(4-methoxyphenyl)-2-pentyl-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid
CFAMM00306952 CHEMBL102969 Bioactive (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-2-butyl-7-(4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid
CFAMM00306918 CHEMBL102314 Bioactive (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-7-(4-methoxyphenyl)-2-(2-methylpropyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid
CFAMM00306936 CHEMBL105591 Bioactive (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-7-(4-methoxyphenyl)-2-propyl-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid
CFAMM00306943 CHEMBL102773 Bioactive (5S,6R,7R)-5-(1,3-benzodioxol-5-yl)-2-ethyl-7-(4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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