CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8706
Family Name Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 inhibitor 1-[[(1S)-1-cyclopropylethyl]amino]-7-(1-methylpyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide family
No. of Seeds 14 No. of Other Members 2
Family Centroid CFAMM00304563 Functional Category Bioactive
Superfamily XL-888 Superfamily
Class Class 1053

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Delavirdine Family 1 68
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Prothrombin Inhibitor Dabigatran Family 7 182
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 5 129
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Purine nucleoside phosphorylase Inhibitor BCX-34 Family 2 31
Transient receptor potential cation channel subfamily V member... 15 457
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Translocator protein Inhibitor Emapunil Family 7 89
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
IPI-145 family 2 4
Histone deacetylase Inhibitor JNJ-26481585 Family 2 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PHA848125 family 13 138
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Smoothened homolog Inhibitor LY2940680 Family 3 18
CC-486 family 7 103
JAK Inhibitor Momelotinib Family 33 83
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
XL-888 family 16 85
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Class II cytokine receptor Ligand IL-10 Family 7 45
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Metabotropic glutamate receptor 5 Ligand N-(1,4-diphenyl-1h-py... 3 35
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 2 3
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Calcitonin gene-related peptide type 1 receptor Ligand Isomer ... 30 31
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-py... 6 37
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Tubulin beta chain Inhibitor 2-m-tolyl-1h-[1,8]naphthyridin-4-... 5 2
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... 3 16
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4
Prothrombin inhibitor SureCN5856722 family 3 16
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... 15 5
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 3
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-amin... 10 48
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Glycogen synthase kinase-3 beta inhibitor AGN-PC-07ZA4D family 1 0
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... 16 40
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 5 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... 6 1
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... 1 4
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Smoothened homolog inhibitor SureCN1091571 family 2 2
Transient receptor potential cation channel subfamily V member... 1 4
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 1 0
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Mitogen-activated protein kinase 14 inhibitor 3mvm family 6 1
Cathepsin K and Potassium voltage-gated channel subfamily H me... 4 7
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 10
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Adenosine receptor A1 ligand AGN-PC-07PMLW family 6 4
Adenosine receptor A2a ligand SureCN14156209 family 3 2
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M4U... 4 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 2 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 3 6
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 3
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 1
Aurora kinase A inhibitor AGN-PC-00EHLC family 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 34 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Platelet-activating factor receptor ligand SureCN7491834 family 28 15
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... 3 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 1 4
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 15 7
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... 3 5
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Metabotropic glutamate receptor 5 ligand SureCN3866791 family 2 10
Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... 17 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 13 3
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
B1 bradykinin receptor ligand 6-(8-fluoro-4-methyl-1-oxophthal... 3 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 0
TGF-beta receptor type-1 ligand 3-[[3-(6-methylpyridin-2-yl)-4... 1 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 0
Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... 21 6
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 11 0
Coagulation factor X and Coagulation factor IX inhibitor pyraz... 6 1
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Mitogen-activated protein kinase 14 inhibitor SureCN3305171 fa... 1 0
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 2 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Scavenger receptor class B member 1 ligand methyl 9-[3-(4,6-di... 2 10
Heat shock protein HSP 90-beta inhibitor N-[(9R)-4-(3H-imidazo... 1 0
Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... 4 0
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Ribosomal protein S6 kinase alpha-3 inhibitor N-(3-ethylimidaz... 2 2
3-phosphoinositide-dependent protein kinase 1 and RAC-alpha se... 10 4
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 3 2
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
Aurora kinase B and Cyclin-dependent kinase 1 inhibitor 7-cycl... 3 16
Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... 5 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 10 0
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Mitogen-activated protein kinase 14 inhibitor methyl 4-[5-(eth... 3 11
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 3 4
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Heat shock protein HSP 90-beta inhibitor 1-(2-amino-4-methylqu... 1 2
Aurora kinase B and Aurora kinase A inhibitor (2S)-1-[4-[[1-[(... 12 4
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... 1 0
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 6 0
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... 2 4
DNA gyrase subunit B inhibitor N-ethyl-5-[6-methoxy-5-(2-oxo-3... 3 0
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... 16 5
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 3 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... 8 1
Growth hormone secretagogue receptor type 1 ligand SureCN36660... 4 14
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... 2 14
Metabotropic glutamate receptor 5 ligand 5-methyl-N-(4-methyl-... 1 2
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
Smoothened homolog inhibitor 3-pyridin-3-yl-N-[1-[[6-[4-[(3-py... 1 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 12 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 3
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Epithelial discoidin domain-containing receptor 1 and Mast/ste... 1 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Tyrosine-protein kinase SYK and Cytochrome P450 2D6 inhibitor ... 3 0
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... 5 1
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-chloro... 2 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 12 3
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 3 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor AGN-... 1 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Type-1 angiotensin II receptor ligand 2-[(2-ethyl-5,7-dimethyl... 5 3
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 13
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Glucocorticoid receptor ligand N-[2-[[[5-amino-1-(4-fluorophen... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 2 0
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN4964150 ... 3 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Egl nine homolog 1 inhibitor 2-[(1,6-diphenylimidazo[4,5-c]pyr... 1 5
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07B2Q... 6 0
Type-1 angiotensin II receptor ligand 2-[[(5-ethylpyrazolo[1,5... 1 0
Mitogen-activated protein kinase kinase kinase 5 inhibitor 4-(... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00CRQ3 fa... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00389951 CHEMBL1835143 Bioactive 1-[[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]amino]-7-(1-methylpyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26197 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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