CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8739
Family Name C-C chemokine receptor type 2 and Potassium voltage-gated channel subfamily H member 2 ligand N-[1-[4-(6-methylpyridin-3-yl)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide family
No. of Seeds 4 No. of Other Members 20
Family Centroid CFAMM00390170 Functional Category Bioactive
Superfamily C-C chemokine receptor type 2 and Potassium voltage-gated channel subfamily H member 2 Binder Superfamily 3
Class Class 4666

Cousin Family NamesSeedsMembers
Macrophage colony-stimulating factor 1 Inhibitor ABT-869 Family 8 56
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Aurora kinase A Inhibitor ABT-348 Family 20 49
Cyclin-dependent kinase 2 Inhibitor N-(5-cyclopropyl-1h-pyrazo... 6 62
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor N-(6-chloro-5-p-toly... 5 9
Glycogen synthase kinase-3 beta Inhibitor (e)-n-(6-(prop-1-eny... 3 0
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Prothrombin inhibitor SureCN5855286 family 15 8
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Cathepsin K and Potassium voltage-gated channel subfamily H me... 5 1
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 1 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 2
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Cell division cycle 7-related protein kinase and Casein kinase... 2 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
C-C chemokine receptor type 2 ligand N-[(2S,3S)-1-[(2,4-dimeth... 1 0
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 5 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 3 0
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 4 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... 2 3
P2X purinoceptor 7 inhibitor N-cyano-N'-(2-methylphenyl)-4-[2-... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00390173 CHEMBL1834631 Bioactive N-[1-(4-phenylcyclohexyl)azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide
CFAMM00390172 CHEMBL1834786 Bioactive N-[1-[4-[3-(dimethylamino)phenyl]cyclohexyl]azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
CFAMM00390185 CHEMBL1834791 Bioactive N-[1-[4-(6-methylpyridin-3-yl)cyclohexyl]azetidin-3-yl]-2-[[1-methyl-5-(trifluoromethyl)indazol-3-yl]amino]acetamide
CFAMM00390170 CHEMBL1834788 Bioactive N-[1-[4-(6-methylpyridin-3-yl)cyclohexyl]azetidin-3-yl]-2-[[5-(trifluoromethyl)-1H-indazol-3-yl]amino]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46031 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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