CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Histamine H4 receptor and Histamine H3 receptor ligand SureCN606149 family
No. of Seeds 17 No. of Other Members 51
Family Centroid CFAMM00316719 Functional Category Bioactive with Natural Product
Superfamily Hepatocyte growth factor receptor and Mast/stem cell growth factor receptor Kit Ligand MP470 Superfamily
Class Class 899

Cousin Family NamesSeedsMembers
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-3328 family 2 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand CGS-15... 24 47
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Adenosine kinase inhibitor 7-[(4aS,7aS)-6-benzyl-3,4,4a,5,7,7a... 2 1
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
5-hydroxytryptamine receptor 1F ligand AGN-PC-075AYH family 2 1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor CHEM... 1 0
Histamine H4 receptor ligand 8-fluoro-4-[(3R)-3-(methylamino)p... 6 1
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 1 1
Prothrombin inhibitor SureCN6925359 family 6 18
Adenosine receptor A2a ligand 9-[(6-chloro-1,3-benzodioxol-5-y... 1 0
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
Adenosine receptor A2a ligand 3-[(2-bromophenyl)methyl]-8-(fur... 2 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 3 0
5-hydroxytryptamine receptor 3A and Histamine H4 receptor liga... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 2


External ID

Functional Category

Molecule Name

CFAMM00316725 CHEMBL1914540 Bioactive 8-chloro-4-(1,4-diazepan-1-yl)-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00316731 CHEMBL1914785 Bioactive 6,8-dichloro-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00316724 CHEMBL1914547 Bioactive 4-[3-(aminomethyl)azetidin-1-yl]-8-chloro-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00316684 CHEMBL1914745 Bioactive 4-(2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[2,3-c]pyrrol-5-yl)-8-chloro-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00316730 CHEMBL1914786 Bioactive 8,9-dichloro-4-[(3R)-3-(methylamino)pyrrolidin-1-yl]-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00316698 CHEMBL1093180 Bioactive STK045847
CFAMM00316669 CHEMBL1914757 Bioactive 8,9-dichloro-4-(4-methylpiperazin-1-yl)-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00316728 CHEMBL1914543 Bioactive 4-[(3R)-3-aminopyrrolidin-1-yl]-8-chloro-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00316681 CHEMBL1914746 Bioactive 4-[(4aR,7aR)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-8-chloro-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00316727 CHEMBL1914542 Bioactive 8-chloro-4-piperazin-1-yl-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00316720 CHEMBL1091875 Bioactive SureCN604512
CFAMM00316694 CHEMBL1914774 Bioactive 8,9-dichloro-4-piperazin-1-yl-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00316711 CHEMBL1914549 Bioactive 4-[(3R)-3-aminopiperidin-1-yl]-8-chloro-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00316726 CHEMBL1914541 Bioactive 8-chloro-4-(4-methylpiperazin-1-yl)-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00316719 CHEMBL1091874 Bioactive SureCN606149
CFAMM00316710 CHEMBL1914548 Bioactive 4-[(3S)-3-aminopiperidin-1-yl]-8-chloro-[1]benzofuro[3,2-d]pyrimidin-2-amine
CFAMM00316672 CHEMBL1914750 Bioactive SureCN605886

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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