CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8752
Family Name Cannabinoid receptor 2 ligand 1-[[4-[5-fluoro-6-(piperidin-1-ylmethyl)pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione family
No. of Seeds 21 No. of Other Members 2
Family Centroid CFAMM00390271 Functional Category Bioactive with Natural Product
Superfamily Cytochrome P450 3A4 and Dipeptidyl peptidase 4 Binder Superfamily
Class Class 1189

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Urotensin-2 receptor Ligand Palosuran Family 4 4
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 5 6
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Endothelin B receptor and Endothelin-1 receptor ligand 2-[[(2R... 17 10
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Cytochrome P450 2C9 and Cytochrome P450 3A4 inhibitor AGN-PC-0... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00390264 CHEMBL1835218 Bioactive 1-[[4-[6-[(3,3-difluoropiperidin-1-yl)methyl]-5-fluoropyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione
CFAMM00390257 CHEMBL1835217 Bioactive 1-[[4-[6-[(3,3-difluoropiperidin-1-yl)methyl]pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione
CFAMM00390270 CHEMBL1835132 Bioactive 3-cyclopropyl-1-[[4-[5-fluoro-6-(piperidin-1-ylmethyl)pyridin-2-yl]phenyl]methyl]imidazolidine-2,4-dione
CFAMM00390263 CHEMBL1835129 Bioactive 3-ethyl-1-[[4-[5-fluoro-6-(piperidin-1-ylmethyl)pyridin-2-yl]phenyl]methyl]imidazolidine-2,4-dione
CFAMM00390256 CHEMBL1835216 Bioactive 1-[[4-[5-fluoro-6-(morpholin-4-ylmethyl)pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione
CFAMM00390269 CHEMBL1835133 Bioactive 3-(cyclopropylmethyl)-1-[[4-[5-fluoro-6-(piperidin-1-ylmethyl)pyridin-2-yl]phenyl]methyl]imidazolidine-2,4-dione
CFAMM00390262 CHEMBL1835128 Bioactive 1-[[4-[6-(piperidin-1-ylmethyl)pyridin-2-yl]phenyl]methyl]-3-(2,2,2-trifluoroethyl)imidazolidine-2,4-dione
CFAMM00390255 CHEMBL1835214 Bioactive 1-[[4-[6-[(3-fluoropiperidin-1-yl)methyl]pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione
CFAMM00390268 CHEMBL1835119 Bioactive 3-(2-methylpropyl)-1-[[4-[6-(piperidin-1-ylmethyl)pyridin-2-yl]phenyl]methyl]imidazolidine-2,4-dione
CFAMM00390261 CHEMBL1835213 Bioactive 1-[[4-[5-fluoro-6-[(3-methylpiperidin-1-yl)methyl]pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione
CFAMM00390274 CHEMBL1835134 Bioactive 3-(cyclobutylmethyl)-1-[[4-[5-fluoro-6-(piperidin-1-ylmethyl)pyridin-2-yl]phenyl]methyl]imidazolidine-2,4-dione
CFAMM00390267 CHEMBL1835220 Bioactive 1-[[4-[6-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-5-fluoropyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione
CFAMM00390260 CHEMBL1835120 Bioactive 1-[[4-[6-(piperidin-1-ylmethyl)pyridin-2-yl]phenyl]methyl]-3-propylimidazolidine-2,4-dione
CFAMM00390273 CHEMBL1835135 Bioactive 3-(2,2-difluoroethyl)-1-[[4-[5-fluoro-6-(piperidin-1-ylmethyl)pyridin-2-yl]phenyl]methyl]imidazolidine-2,4-dione
CFAMM00390253 CHEMBL1835125 Bioactive 3-cyclobutyl-1-[[4-[6-(piperidin-1-ylmethyl)pyridin-2-yl]phenyl]methyl]imidazolidine-2,4-dione
CFAMM00390266 CHEMBL1835222 Bioactive 3-cyclopropyl-1-[[4-[6-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-5-fluoropyridin-2-yl]phenyl]methyl]imidazolidine-2,4-dione
CFAMM00390259 CHEMBL1835215 Bioactive 1-[[4-[5-fluoro-6-[(3-fluoropiperidin-1-yl)methyl]pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione
CFAMM00390272 CHEMBL1835130 Bioactive 1-[[4-[5-fluoro-6-(piperidin-1-ylmethyl)pyridin-2-yl]phenyl]methyl]-3-propylimidazolidine-2,4-dione
CFAMM00390265 CHEMBL1835121 Bioactive 3-ethyl-1-[[4-[6-(piperidin-1-ylmethyl)pyridin-2-yl]phenyl]methyl]imidazolidine-2,4-dione
CFAMM00390258 CHEMBL1835126 Bioactive 3-(cyclopropylmethyl)-1-[[4-[6-(piperidin-1-ylmethyl)pyridin-2-yl]phenyl]methyl]imidazolidine-2,4-dione
CFAMM00390271 CHEMBL1835131 Bioactive 1-[[4-[5-fluoro-6-(piperidin-1-ylmethyl)pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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