CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8770
Family Name Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyrrolidin-3-yl]-4-pyrazol-1-ylbenzamide family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00390373 Functional Category Bioactive
Superfamily TGF-beta receptor type-1 Ligand LY2157299 Superfamily
Class Class 1276

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Growth hormone receptor Ligand EP-51216 Family 34 390
Interleukin-1 beta and Interleukin-6 Inhibitor Ibudilast Family 2 11
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Neutrophil elastase Inhibitor (4-bromo-1h-pyrazol-1-yl)(o-toly... 5 4
Adenosine receptor A3 Ligand 2-phenyl-2h-pyrazolo[4,3-d]pyrimi... 2 7
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... 10 10
5-hydroxytryptamine receptor 2A ligand AGN-PC-04RTMN family 7 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Hepatocyte growth factor receptor ligand 9-[[3-methoxypropyl(m... 17 2
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 12
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 1 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
cAMP-dependent protein kinase catalytic subunit PRKX and Rho-a... 1 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Calcitonin gene-related peptide type 1 receptor ligand 3-[1-[4... 5 3
Hepatocyte growth factor receptor ligand 5-(3-methyl-1,2-thiaz... 5 2
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Vascular endothelial growth factor receptor 2 and Angiopoietin... 14 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Cathepsin S inhibitor 4-acetamido-N-[(S)-[1-(1-cyanocyclopropy... 4 0
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 4 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
D(3) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 2 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R6UP family 2 0
Tyrosyl-DNA phosphodiesterase 1 and Huntingtin inhibitor CHEMB... 1 8
Prolyl endopeptidase inhibitor 4-phenyl-1-[(2S,4S)-4-(4-pyridi... 2 1
Metabotropic glutamate receptor 5 ligand 3-methyl-1-[2-[3-(tri... 3 1
TGF-beta receptor type-1 ligand SureCN373106 family 4 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00390373 CHEMBL1835998 Bioactive N-methyl-N-[(3R)-1-propan-2-ylpyrrolidin-3-yl]-4-pyrazol-1-ylbenzamide
CFAMM00390372 CHEMBL1835999 Bioactive N-[(3R)-1-cyclobutylpyrrolidin-3-yl]-N-methyl-4-pyrazol-1-ylbenzamide
CFAMM00390375 CHEMBL1836000 Bioactive N-[(3R)-1-cyclopentylpyrrolidin-3-yl]-N-methyl-4-pyrazol-1-ylbenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

43672 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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