CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8789
Family Name Toll-like receptor 7 ligand 4-amino-1-[[6-(2-pyrrolidin-1-ylethoxy)pyridin-3-yl]methyl]-6-(trifluoromethyl)-3H-imidazo[4,5-c]pyridin-2-one family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00390510 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Receptor tyrosine-protein kinase erbB-2 Inhibitor Pazopanib + Tyverb/tykerb Superfamily
Class Class 1037

Cousin Family NamesSeedsMembers
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
AP26113 family 16 90
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(... 12 13
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-(2-hy... 24 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Lysine--tRNA ligase and Tyrosine-protein kinase Lyn inhibitor ... 1 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00390508 CHEMBL2315158 Bioactive 6-amino-2-(butylamino)-9-[[6-[2-(dimethylamino)ethoxy]pyridin-3-yl]methyl]-7H-purin-8-one
CFAMM00390510 CHEMBL1836884 Bioactive 4-amino-1-[[6-(2-pyrrolidin-1-ylethoxy)pyridin-3-yl]methyl]-6-(trifluoromethyl)-3H-imidazo[4,5-c]pyridin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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