CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM88
Family Name Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ligand (3R)-3-[[2-(2,6-dimethoxyphenoxy)ethylamino]methyl]-2-phenyl-2,3-dihydrochromen-4-one family
No. of Seeds 4 No. of Other Members 10
Family Centroid CFAMM00275851 Functional Category Bioactive with Natural Product
Superfamily Muscarinic acetylcholine receptor Ligand Flavoxate Superfamily
Class Class 288

Cousin Family NamesSeedsMembers
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Serotonin re-uptake Inhibitor Paroxetine Family 6 19
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
DNA Binder Methoxsalen Family 10 1638
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Beta-2 adrenergic receptor Ligand Salmeterol Xinafoate Family 9 51
Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family 4 124
5-hydroxytryptamine receptor 1A Ligand MN-305 Family 12 26
Heat shock protein 90, putative Inhibitor KW-2478 Family 1 14
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Acetylcholinesterase Inhibitor AP-2238 Family 2 109
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 18
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 1 0
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 7 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 7
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 14 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Cathepsin D inhibitor (E)-N-butyl-4-[1-(3,4,5-trimethoxybenzoy... 1 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 7
Putative NP ZINC08790414 Family 23 0
Putative NP ZINC02127056 Family 4 1
2-amino-3-methylpentanoate NP 2-((3-(4-fluorophenoxy)-4-oxo-4h... 13 2
NP Molport-006-318-109 Family 13 0
Putative NP ZINC04085259 Family 3 0
4-(7-((2-amino-3-phenylpropanoyl)oxy)-5-hydroxy-4-oxo-4H-chrom... 3 0
NP 5-hydroxy-4-oxo-2-phenyl-4h-chromen-7-yl 2-((tert-butoxycar... 19 0
2-(2,4-dimethoxyphenyl)-2,3,6,7,11,12-hexahydro-[1,4]dioxepino... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00306964 CHEMBL2111606 Bioactive (2S,3R)-3-[[2-(2,6-dimethoxyphenoxy)ethylamino]methyl]-2-phenyl-2,3-dihydrochromen-4-one
CFAMM00306965 CHEMBL44403 Bioactive 2-[[2-(2,6-dimethoxyphenoxy)ethylamino]methyl]-4-phenyl-3,4-dihydro-2H-naphthalen-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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