CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM8805
Family Name Melatonin receptor type 1A and Melatonin receptor type 1B ligand N-[[(1R)-2-[2-(4-phenylbutyl)-1-benzofuran-4-yl]cyclopropyl]methyl]acetamide family
No. of Seeds 7 No. of Other Members 18
Family Centroid CFAMM00390687 Functional Category Bioactive with Natural Product
Superfamily Melatonin receptor type 1A and Melatonin receptor type 1B Binder Superfamily
Class Class 769

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Muscarinic acetylcholine receptor M3 Ligand Darifenacin Family 3 17
Histamine H3 receptor Ligand ABT-239 Family 8 20
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Microsomal triglyceride transfer protein large subunit Inhibit... 3 103
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Estradiol 17-beta-dehydrogenase 1 Inhibitor N(furan-2-ylmethyl... 2 1
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 4 18
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Melatonin receptor type 1A and Melatonin receptor type 1B Liga... 33 98
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Fatty-acid amide hydrolase 1 Inhibitor Furan-2-ylmethylcarbami... 1 105
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 2
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 62
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 2
Peroxisome proliferator-activated receptor delta and Peroxisom... 20 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 8 36
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 4
Endothelin-1 receptor and Endothelin B receptor ligand (2R,3R,... 3 2
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Sodium-dependent dopamine transporter and Sigma non-opioid int... 7 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 10 8
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 2 2
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 10
Lethal(3)malignant brain tumor-like protein 1 and Lysine-speci... 1 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Hypoxia-inducible factor 1-alpha and Cytochrome P450 2D6 inhib... 1 2
Histamine H3 receptor ligand SureCN2786002 family 8 3
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Histamine H3 receptor ligand SureCN2784769 family 12 2
Histamine H3 receptor ligand SureCN2785131 family 7 1
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Mu-type opioid receptor ligand AGN-PC-075GAC family 16 8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 2 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 2 4
Dipeptidyl peptidase 4 inhibitor SureCN5777647 family 1 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 3 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
D(3) dopamine receptor ligand S33084 family 1 1
Gonadotropin-releasing hormone receptor ligand N-[[4-[(diamino... 6 4
Arachidonate 5-lipoxygenase inhibitor methyl 5-[1-(2-butyl-1-b... 2 4
Arachidonate 5-lipoxygenase inhibitor 1-hydroxy-1-[1-[2-(3,4,5... 2 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00390699 CHEMBL186736 Bioactive N-[[(1R)-2-[2-(4-phenylbutyl)-1-benzofuran-4-yl]cyclopropyl]methyl]propanamide
CFAMM00390701 CHEMBL363947 Bioactive N-[[(1R)-2-[2-(4-phenylbutyl)-1-benzofuran-4-yl]cyclopropyl]methyl]butanamide
CFAMM00390687 CHEMBL186586 Bioactive N-[[(1R)-2-[2-(4-phenylbutyl)-1-benzofuran-4-yl]cyclopropyl]methyl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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